Use of Dermal LD50 as a Criterion for Skin Notation (Letter to the Editor)

Details

• Personal Author:
  Ahlers HW ; Boeniger, Mark F. ; Chen CP
• Description:
  We read with interest the recent article by Czerczak and Kupczewska entitled "Assignment of Skin Notation for Maximum Allowable Concentration (MAC) List in Poland" in the March 2002 issue of Applied Occupational and Environmental Hygiene. Czerczak and Kupczewska analyzed the organic chemicals from the Polish MAC list for skin notation (the Sk index) and concluded that ". . . the dermal dose LD50s [lethal dose 50 percent] determined on experimental animals ought to be adopted as the fundamental criterion for providing a substance with the percutaneous absorption notation in the MAC list." We would like to comment on the need for a careful analysis of the data underlying a dermal LD50 or an occupational exposure limit (OEL) before using either of them to assess the appropriateness of a dermal hazard notation. [Description provided by NIOSH]
• Subjects:
  Animals Chemistry Decision Making Hazardous Substances Occupational Exposure Occupational Health Safety Skin Skin Absorption
• Keywords:
  Analytical-processes Animal-studies Chemical-properties Decision-making Dermal-absorption Dermal-exposure Dose-response Exposure-levels Exposure-limits Information-systems Lethal-dose Occupational-exposure Skin-absorption Skin-exposure Toxic-effects

  More +
• ISSN:
  1047-322X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  154-155
• Volume:
  18
• Issue:
  3
• NIOSHTIC Number:
  nn:20023261
• Citation:
  Appl Occup Environ Hyg 2003 Mar; 18(3):154-155
• CAS Registry Number:
  2-Chloroethanol (CAS RN 107-07-3) ; Diazinon (CAS RN 333-41-5) ; Ethion (CAS RN 563-12-2) ; Parathion-methyl (CAS RN 2Furfuryl alcohol (CAS RN 98-00-0)) ; Phorate (CAS RN 298-02-2) ; Vinylcyclohexene diepoxide (CAS RN 106-87-6)
• Federal Fiscal Year:
  2003
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Peer Reviewed:
  False
• Source Full Name:
  Applied Occupational and Environmental Hygiene
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b131758a9f1a896c2ffb746f09ea963e594f6442a1f343dc69bb675f66963cdbb75f3c16539029ccde6d72c3c6e81b0281ffab242daf986f172b337c46fa5b6a
• Download URL:
  https://stacks.cdc.gov/view/cdc/195794/cdc_195794_DS1.pdf
• File Type:
  [PDF - 59.60 KB ]