DNA Damage, DNA Repair, and Mutagenesis

Details

• Personal Author:
  Poirier MC ; Weston A
• Description:
  DNA damage consists of (a) formation of carcinogen-DNA adducts and other chemical modifications of DNA bases and (b) alternations in DNA ultrastructure (DNA strand cross-links/DNA strand breaks/chromatid exchange/chromosomal loss). DNA damange can be induced by endogenous processes and by exogenous chemical and physical agents. A potential consequence of DNA damage is mutagenesis, i.e., a permanent alteration in DNA structure that produces miscopying of information during DNA replication and yields abnormal gene products (proteins). The process of carcinogenesis is considered to require mutations in multiple cricical genes, and the risk of cancer is reduced when potentially mutagenic DNA damage is removed by DNA repair. [Description provided by NIOSH]
• Subjects:
  Carcinogens DNA Mutagens Neoplasms Occupational Health Safety
• Keywords:
  Cancer DNA-adducts DNA-damage Gene-mutation Mutagenesis Mutation
• ISBN:
  0122275551
• Publisher:
  Academic Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  79-87
• Volume:
  2
• NIOSHTIC Number:
  nn:20023246
• Citation:
  Encyclopedia of cancer, second edition. Bertino JR, ed. San Diego, CA: Academic Press, 2002 Jul; 2:79-87
• Editor(s):
  Bertino JR
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Peer Reviewed:
  False
• Source Full Name:
  Encyclopedia of cancer, second edition
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:67825cf8f30791faf5f4812393d31b2e4aae68e698d146909472e5bf3f9084f17784a2e11b339338283b22d89dc3614d59d9ded03055858418e8b58f3d4ccacb
• Download URL:
  https://stacks.cdc.gov/view/cdc/195780/cdc_195780_DS1.pdf
• File Type:
  [PDF - 2.50 MB ]