Cumulative risk: toxicity and interactions of physical and chemical stressors

Details

• Personal Author:
  Boekelheide K ; Catlin N ; Gordon CJ ; Morata, Thais C. ; Rider CV ; Selgrade MK ; Sexton K ; Simmons JE
• Description:
  Recent efforts to update cumulative risk assessment procedures to incorporate nonchemical stressors ranging from physical to psychosocial reflect increased interest in consideration of the totality of variables affecting human health and the growing desire to develop community-based risk assessment methods. A key roadblock is the uncertainty as to how nonchemical stressors behave in relationship to chemical stressors. Physical stressors offer a reasonable starting place for measuring the effects of nonchemical stressors and their modulation of chemical effects (and vice versa), as they clearly differ from chemical stressors; and doses of many physical stressors are more easily quantifiable than those of psychosocial stressors. There is a commonly held belief that virtually nothing is known about the impact of nonchemical stressors on chemically mediated toxicity or the joint impact of coexposure to chemical and nonchemical stressors. Although this is generally true, there are several instances where a substantial body of evidence exists. A workshop titled Cumulative Risk: Toxicity and Interactions of Physical and Chemical Stressors held at the 2013 Society of Toxicology Annual Meeting provided a forum for discussion of research addressing the toxicity of physical stressors and what is known about their interactions with chemical stressors, both in terms of exposure and effects. Physical stressors including sunlight, heat, radiation, infectious disease, and noise were discussed in reference to identifying pathways of interaction with chemical stressors, data gaps, and suggestions for future incorporation into cumulative risk assessments. [Description provided by NIOSH]
• Subjects:
  Communicable Diseases Hot Temperature Noise Occupational Health Radiation Risk Assessment Risk Factors Safety Temperature
• Keywords:
  Author Keywords: Cumulative Risk Diseases Heat Heat-exposure Infectious-diseases Infectious Disease Joint Action Nonchemical Stressors Physical-stress Physiological-effects Physiology Radiation Radiation-effects Radiation-exposure Risk-factors Stress Sunlight Temperature Temperature-effects

  More +
• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; Ohio ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5 ; Rhode Island
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  3-11
• Volume:
  137
• Issue:
  1
• NIOSHTIC Number:
  nn:20043642
• Citation:
  Toxicol Sci 2014 Jan; 137(1):3-11
• Contact Point Address:
  Cynthia V. Rider, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, PO Box 12233, MD: K2-12, Research Triangle Park, NC 27709
• Email:
  ridercv@niehs.nih.gov
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Construction ; Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Toxicological Sciences
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e0d7ed78cd4df6d43a83ec6a9298add5ae91c4463d08edc3287c357c91ee009858c7940e6831457af27cc6973c2e73f8ef993cf17c9c66a2b384bd7a027a852a
• Download URL:
  https://stacks.cdc.gov/view/cdc/195486/cdc_195486_DS1.pdf
• File Type:
  [PDF - 1.03 MB ]