The role of nodose ganglia in the regulation of cardiovascular function following pulmonary exposure to ultrafine titanium dioxide

Details

• Personal Author:
  Castranova, Vincent ; Chen T-H ; Cumpston JL ; Kan H ; Kashon ML ; Leonard, Stephanie ; Lin Y-C ; Munson AE ; Wu Z
• Description:
  The inhalation of nanosized air pollutant particles is a recognised risk factor for cardiovascular disease; however, the link between occupational exposure to engineered nanoparticles and adverse cardiovascular events remains unclear. In the present study, the authors demonstrated that pulmonary exposure of rats to ultrafine titanium dioxide (UFTiO2) significantly increased heart rate and depressed diastolic function of the heart in response to isoproterenol. Moreover, pulmonary inhalation of UFTiO2 elevated mean and diastolic blood pressure in response to norepinephrine. Pretreatment of the rats ip with the transient receptor potential (TRP) channel blocker ruthenium red inhibited substance P synthesis in nodose ganglia and associated functional and biological changes in the cardiovascular system. In conclusion, the effects of pulmonary inhalation of UFTiO2 on cardiovascular function are most likely triggered by a lung-nodose ganglia-regulated pathway via the activation of TRP channels in the lung. [Description provided by NIOSH]
• Subjects:
  Blood Cardiovascular Diseases Cardiovascular System Environmental Monitoring Laboratories Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Nanoparticles Blood-pressure Cardiopulmonary-function Cardiopulmonary-system-disorders Cardiovascular-function Cardiovascular-system-disorders Cardiovascular System Dioxides Exposure-assessment Heart-rate Inhalation-studies Inhalation Study Laboratory-animals Laboratory-testing Nanotechnology Neural Pathways Pulmonary-function Pulmonary-system-disorders

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• ISSN:
  1743-5390
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  447-454
• Volume:
  8
• Issue:
  4
• NIOSHTIC Number:
  nn:20043088
• Citation:
  Nanotoxicology 2014 Jun; 8(4):447-454
• Contact Point Address:
  Hong Kan, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, PPRB, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  hvn4@cdc.gov
• CAS Registry Number:
  Isoproterenol (CAS RN 7683-59-2) ; Titania (CAS RN 13463-67-7)
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Construction
• Peer Reviewed:
  True
• Source Full Name:
  Nanotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:32e5ee6d2a8d16256b355aea45ab80118bdcbd2c762e0856b699daf8fd9a37d9a5a6a1d96e9232a6af6b00968420f2ee84a2f1242309e1e38b4303e30f522b50
• Download URL:
  https://stacks.cdc.gov/view/cdc/195102/cdc_195102_DS1.pdf
• File Type:
  [PDF - 171.53 KB ]