Pulmonary and cardiovascular responses of rats to inhalation of silver nanoparticles

Details

• Personal Author:
  Castranova, Vincent ; Frazer DG ; Hackley VA ; Kan H ; Kenyon A ; Krajnak, Kristine M. ; MacCuspie RI ; McKinney W ; Roberts, Jennifer R. ; Thomas TA ; Waugh, Stacey
• Description:
  Exposure to wet aerosols generated during use of spray products containing silver (Ag) has not been evaluated. The goal was to assess the potential for cardiopulmonary toxicity following an acute inhalation of wet silver colloid. Rats were exposed by inhalation to a low concentration (100 µg/m(3)) using an undiluted commercial antimicrobial product (20 mg/L total silver; approximately 33 nm mean aerodynamic diameter [MAD]) or to a higher concentration (1000 µg/m(3)) using a suspension (200 mg/L total silver; approximately 39 nm MAD) synthesized to possess a similar size distribution of Ag nanoparticles for 5 h. Estimated lung burdens from deposition models were 0, 1.4, or 14 µg Ag/rat after exposure to control aerosol, low, and high doses, respectively. At 1 and 7 d postexposure, the following parameters were monitored: pulmonary inflammation, lung cell toxicity, alveolar air/blood barrier damage, alveolar macrophage activity, blood cell differentials, responsiveness of tail artery to vasoconstrictor or vasodilatory agents, and heart rate and blood pressure in response to isoproterenol or norepinephrine, respectively. Changes in pulmonary or cardiovascular parameters were absent or nonsignificant at 1 or 7 d postexposure with the exceptions of increased blood monocytes 1 d after high-dose Ag exposure and decreased dilation of tail artery after stimulation, as well as elevated heart rate in response to isoproterenol 1 d after low-dose Ag exposure, possibly due to bioavailable ionic Ag in the commercial product. In summary, short-term inhalation of nano-Ag did not produce apparent marked acute toxicity in this animal model. [Description provided by NIOSH]
• Subjects:
  Aerosols Blood Cardiovascular Diseases Cardiovascular System Environmental Monitoring Hazardous Substances Laboratories Lung Lung Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety Silver

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• Keywords:
  Aerosol-particles Blood-pressure Cardiopulmonary-function Cardiopulmonary-system Cardiopulmonary-system-disorders Cardiovascular-system-disorders Cellular-reactions Colloids Exposure-assessment Heart-rate Inhalation-studies Laboratory-animals Laboratory-testing Lung-burden Lung-disorders Nanotechnology Particle-aerodynamics Pulmonary-system-disorders Respiratory-system-disorders Silver-compounds Toxic-materials Vasoactive-agents

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• ISSN:
  1528-7394
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  76
• Issue:
  11
• NIOSHTIC Number:
  nn:20043085
• Citation:
  J Toxicol Environ Health A 2013 Apr; 76(11):651-668
• Contact Point Address:
  Jenny R. Roberts, PhD, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd. (M/S 2015), Morgantown, WV 26505, USA
• Email:
  jur6@cdc.gov
• CAS Registry Number:
  Isoproterenol (CAS RN 7683-59-2) ; Silver (CAS RN 7440-22-4)
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:83d6c2097417ed175a648c7704ba0ea6fa421075a2e0f6c3897383b5655ca80a645101becb57e8491e1b52906480888b9b6e66b961f6d90ee223c04ae98edc2d
• Download URL:
  https://stacks.cdc.gov/view/cdc/195099/cdc_195099_DS1.pdf
• File Type:
  [PDF - 1.38 MB ]