Maternal periconceptional occupational exposure to pesticides and selected musculoskeletal birth defects

Details

• Personal Author:
  Bell E ; Cao Y ; Chapman B ; Druschel C ; Herdt-Losavio M ; Kielb C ; Lawson C ; Lin S ; Olney RS ; Rocheleau CM ; Romitti PA ; Stewart P ; Waters M
• Corporate Authors:
  National Birth Defects Prevention Network
• Description:
  This population-based U.S. study investigated the association between major musculoskeletal malfor-mations and periconceptional maternal occupational pesticide exposure for a wide range of occupations.We conducted a multi-site case-control analysis using data from the National Birth Defects Preven-tion Study among employed women with due dates from October 1, 1997 through December 31, 2002.Cases included 871 live-born, stillborn, or electively terminated fetuses with isolated craniosynostosis,gastroschisis, diaphragmatic hernia, or transverse limb deficiencies. Controls included 2857 live-borninfants without major malformations. Using self-reported maternal occupational information, an indus-trial hygienist used a job-exposure matrix and expert opinion to evaluate the potential for exposure toinsecticides, herbicides or fungicides for each job held during one month pre-conception through threemonths post-conception. Exposures analyzed included any exposure (yes/no) to pesticides, to insecticidesonly, to both insecticides and herbicides (I + H) and to insecticides, herbicides and fungicides (I + H + F). Weused logistic regression to evaluate the association between exposures and defects, controlling for infantand maternal risk factors. Occupational exposure to I + H + F was associated with gastroschisis amonginfants of women aged 20 years or older (adjusted odds ratio [aOR] = 1.88; 95% confidence interval [CI]:1.16-3.05), but not for women under age 20 (aOR = 0.48; 95% CI: 0.20-1.16). We found no significantassociations for the other defects. Additional research is needed to validate these findings in a separatepopulation. [Description provided by NIOSH]
• Subjects:
  Insecticides Musculoskeletal Diseases Musculoskeletal System Occupational Health Pregnancy Risk Assessment Risk Factors Safety Women
• Keywords:
  Author Keywords: Pesticides Birth-defects Craniosynostosis Diaphragmatic Hernia Etiology Exposure-levels Gastroschisis Humans Maternal Occupational Exposure Musculoskeletal-system Musculoskeletal-system-disorders Pesticides Pesticides-and-agricultural-chemicals Prenatal-exposure Risk-factors Transverse Limb Deficiencies

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• ISSN:
  1438-4639
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Iowa ; New York ; Ohio ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 7 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  248-254
• Volume:
  217
• Issue:
  2
• NIOSHTIC Number:
  nn:20043067
• Citation:
  Int J Hyg Environ Health 2014 Mar; 217(2-3):248-254
• Contact Point Address:
  Christine Kielb, NYS Department of Health, Corning Tower Room 1203,Empire State Plaza, Albany, NY 12237
• Email:
  clk03@health.state.ny.us
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  International Journal of Hygiene and Environmental Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a88b81fb7bc7b24eb55c0da2c2e9b378ed51212c9558b4d029d0efd77a3bc18b88890e86a3adc58db9ed0ae8c5c93b0ba2081f515f2c7116f41f85e559d91385
• Download URL:
  https://stacks.cdc.gov/view/cdc/195085/cdc_195085_DS1.pdf
• File Type:
  [PDF - 493.00 KB ]