International guidelines for the in vivo assessment of skin properties in non-clinical settings: part 2. Transepidermal water loss and skin hydration

Details

• Personal Author:
  Agner T ; Chou T-C ; Du Plessis, J. J. L. ; Eloff F ; Franken A ; Holness L ; John SM ; Kudla I ; Nixon R ; Stefaniak, Aleksandr B. ; Steiner M
• Description:
  Background: There is an emerging perspective that it is not sufficient to just assess skin exposure to physical and chemical stressors in workplaces, but that it is also important to assess the condition, i.e. skin barrier function of the exposed skin at the time of exposure. The workplace environment, representing a non-clinical environment, can be highly variable and difficult to control, thereby presenting unique measurement challenges not typically encountered in clinical settings. Methods: An expert working group convened a workshop as part of the 5th International Conference on Occupational and Environmental Exposure of Skin to Chemicals (OEESC) to develop basic guidelines and best practices (based on existing clinical guidelines, published data, and own experiences) for the in vivo measurement of transepidermal water loss (TEWL) and skin hydration in non-clinical settings with specific reference to the workplace as a worst-case scenario. Results: Key elements of these guidelines are: (i) to minimize or recognize, to the extent feasible, the influences of relevant endogenous-, exogenous-, environmental- and measurement/instrumentation-related factors; (ii) to measure TEWL with a closed-chamber type instrument; (iii) report results as a difference or percent change (rather than absolute values); and (iv) accurately report any notable deviations from this guidelines. Conclusion: It is anticipated that these guidelines will promote consistent data reporting, which will facilitate inter-comparison of study results. [Description provided by NIOSH]
• Subjects:
  Biological Factors Chemistry Environmental Health Environmental Monitoring Occupational Health Safety Skin Water Purification Workplace
• Keywords:
  Author Keywords: Skin Hydration Biological-factors Chemical-properties Data-processing Environmental-factors Exposure-assessment Guideline Health-protection Health-standards In-vivo-studies Non-clinical Physiological-factors Skin-exposure Skin-protection Skin Barrier Stratum Corneum Transepidermal Water Loss Water-analysis Work-environment

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• ISSN:
  0909-752X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  265-278
• Volume:
  19
• Issue:
  3
• NIOSHTIC Number:
  nn:20043039
• Citation:
  Skin Res Technol 2013 Aug; 19(3):265-278
• Contact Point Address:
  Johan du Plessis, North West Univ, Sch Physiol Nutr & Consumer Sci, Private Bag X6001, ZA-2520 Potchefstroom, North West Prov, South Africa
• Email:
  Johan.duPlessis@nwu.ac.za
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Skin Research and Technology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:976ba1fcc83155af01561bd9a2a896aed1eaca237ee542022d1783d923c6d7d652cd7906a1312e7b89907fededab6726525c7ffde4ff18e0329d1cd08c4e8d57
• Download URL:
  https://stacks.cdc.gov/view/cdc/195063/cdc_195063_DS1.pdf
• File Type:
  [PDF - 114.00 KB ]