Effects of popcorn butter flavorings, diacetyl and 2,3-pentanedione, on isolated airway preparations

Details

• Personal Author:
  Fedan, Jeffery S. ; Shimko MJ ; Thompson JA ; Zaccone EJ
• Description:
  RATIONALE: "Popcorn workers' lung" is a life-threatening, fixed obstructive pulmonary disease caused by inhalation of butter flavoring vapor. Histological evidence from animals exposed by inhalation to the butter flavorings, diacetyl (2,3-butanedione), and a diacetyl substitute, 2,3-pentanedione (acetyl proprionyl), demonstrated vapor-concentration-dependent damage to epithelial cells. Because nothing is known about the effects of diacetyl and 2,3-pentanedione on airway smooth muscle (ASM), we investigated the pharmacological activity of these two flavorings on isolated airways. METHODS: In rat isolated, perfused tracheas, the contractile and relaxant effects of diacetyl and 2,3-pentanedione applied to the serosal and mucosal surfaces of intact and denuded contracted (MCh; 3x10-5 M) tracheas were evaluated. RESULTS: Concentrations of both agents greater than 3 mM resulted in ASM relaxation. Relaxation of the trachea by diacetyl and 2,3-pentanedione was not dependent upon the presence of the epithelium. CONCLUSIONS: Our findings indicate that both flavorings are similar in their effects as ASM relaxants. [Description provided by NIOSH]
• Subjects:
  Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Solvents
• Keywords:
  Cell-damage Diseases Lung-disease Pharmacology Pulmonary-disorders Pulmonary-function Pulmonary-system Pulmonary-system-disorders Respiration Respiratory-system-disorders Vapors

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• ISSN:
  0892-6638
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20042865
• Citation:
  FASEB J 2013 Apr; 27(Meeting Abstracts):1107.16
• CAS Registry Number:
  Butanedione (CAS RN 431-03-8)
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Construction
• Peer Reviewed:
  False
• Source Full Name:
  The FASEB Journal
• Supplement:
  Meeting Abstracts
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bb04b9870b8034544904ce48f4e4f86a29461f9f450838c4620dd12e13c0fa0ba8102fbeda2214de7c82fc918f6067768ac03961ac2b2b0842e6384f8f452087
• Download URL:
  https://stacks.cdc.gov/view/cdc/194949/cdc_194949_DS1.pdf
• File Type:
  [PDF - 26.98 KB ]