Cohort mortality study of garment industry workers exposed to formaldehyde: update and internal comparisons

Details

• Personal Author:
  Hein, Misty J. ; Meyers, Alysha R. ; Pinkerton LE
• Description:
  BACKGROUND: To further evaluate the association between formaldehyde and leukemia, we extended follow-up through 2008 for a cohort mortality study of 11,043 US formaldehyde-exposed garment workers. METHODS: We computed standardized mortality ratios and standardized rate ratios stratified by year of first exposure, exposure duration, and time since first exposure. Associations between exposure duration and rates of leukemia and myeloid leukemia were further examined using Poisson regression models. RESULTS: Compared to the US population, myeloid leukemia mortality was elevated but overall leukemia mortality was not. In internal analyses, overall leukemia mortality increased with increasing exposure duration and this trend was statistically significant. CONCLUSIONS: We continue to see limited evidence of an association between formaldehyde and leukemia. However, the extended follow-up did not strengthen previously observed associations. In addition to continued epidemiologic research, we recommend further research to evaluate the biological plausibility of a causal relation between formaldehyde and leukemia. [Description provided by NIOSH]
• Subjects:
  Epidemiology Formaldehyde Hematologic Diseases Morbidity Mortality Occupational Health Risk Assessment Risk Factors Safety Textile Industry Workplace

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• Keywords:
  Analytical-processes Author Keywords: Formaldehyde Blood-disorders Cohort Studies Exposure-levels Formaldehydes Garment-workers Leukemia Morbidity-rates Mortality-rates Occupational Exposure Retrospective Studies Risk-factors Statistical-analysis Textile-finishing Textile-workers Textiles Work-environment Workers

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  56
• Issue:
  9
• NIOSHTIC Number:
  nn:20042858
• Citation:
  Am J Ind Med 2013 Sep; 56(9):1027-1039
• Contact Point Address:
  Alysha R.Meyers, PhD, Division of Surveillance, Hazard Evaluations and Field Studies, Industrywide Studies Branch,The National Institute for Occupational Safety and Health, 4676 Columbia Parkway,R-15,Cincinnati,OH 45226
• Email:
  armeyers@cdc.gov
• CAS Registry Number:
  Formaldehyde (CAS RN 50-00-0)
• Federal Fiscal Year:
  2013
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c0ff58cef665ace3b28f00d1cf78ac898f03a1bc21df4ebc6ca9df407df559b3b6a327e74589566aacc666d7a335c4138227029fd045e9a058c64d3093647e3b
• Download URL:
  https://stacks.cdc.gov/view/cdc/194943/cdc_194943_DS1.pdf
• File Type:
  [PDF - 254.03 KB ]