Cancer Mortality Update with an Exposure Response Analysis Among Styrene-Exposed Workers in the Reinforced Plastics Boatbuilding Industry

Details

• Personal Author:
  Bertke SJ ; Daniels, Robert D. ; Yiin JH
• Description:
  Background: There is sparse and inconsistent evidence of an association between styrene exposure and cancer. Methods: This study examines mortality patterns in a previously studied cohort of 5201 workers employed in two Washington boat-building facilities, extending follow-up 5 years. Standardized mortality ratios (SMR) were calculated using state rates as referent. Cox regression calculated rate ratios (RR) per year employed in styrene- exposed exposed jobs. Results: No excess deaths from lymphohematopoietic cancers (LHCs) were observed (SMR: 0.99, 95%CI: 0.74-1.30) when compared to the referent population; however, the relative risk increased with duration of employment in internal analyses. Conversely, lung cancer mortality was significantly elevated (SMR: 1.24, 95%CI: 1.08-1.41), but there was no evidence of a dose-response relationship. Conclusion: We found evidence that occupational exposure to styrene was associated with increased LHC risk, while no such association was observed for lung cancer. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Environmental Exposure Men Morbidity Mortality Neoplasms Occupational Health Risk Assessment Risk Factors Safety Styrene Women Workplace

  More +
• Keywords:
  Author Keywords: Cox Regression Boat Manufacturing Industry Cancer Cohort Studies Exposure Levels Exposure Response Humans Leukemia Morbidity Rates Mortality Rates Plastic Products Reinforced Plastics Risk Factors Work Environment Workers

  More +
• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  61
• Issue:
  7
• NIOSHTIC Number:
  nn:20051345
• Citation:
  Am J Ind Med 2018 Jul; 61(7):566-571
• Contact Point Address:
  Stephen J. Bertke, PhD, National Institute for Occupational Safety and Health, 1090 Tusculum Ave, MailStop R-15, Cincinnati, 45226 OH
• Email:
  sbertke@cdc.gov
• CAS Registry Number:
  Styrene (CAS RN 100-42-5)
• Federal Fiscal Year:
  2018
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:785ad29959e87128fc61305c4fea6c9f312b3c023373866286a457fef75f021279f3bda821abd954f4bb5ab3c4294628a720a0df9513e9d8b9b3b1a96ba76cf9
• Download URL:
  https://stacks.cdc.gov/view/cdc/211358/cdc_211358_DS1.pdf
• File Type:
  [PDF - 364.03 KB ]