Analysis of finite dose dermal absorption data: implications for dermal exposure assessment

Details

• Personal Author:
  Bunge AL ; Chen C-P ; Cherrie JW ; Dotson, G. Scott ; Frasch, H. Fredrick ; Kasting GB ; Kissel JC ; Sahmel J ; Semple S ; Wilkinson S
• Description:
  A common dermal exposure assessment strategy estimates the systemic uptake of chemical in contact with skin using the fixed fractional absorption approach: the dermal absorbed dose is estimated as the product of exposure and the fraction of applied chemical that is absorbed, assumed constant for a given chemical. Despite the prominence of this approach there is little guidance regarding the evaluation of experiments from which fractional absorption data are measured. An analysis of these experiments is presented herein, and limitations to the fixed fractional absorption approach are discussed. The analysis provides a set of simple algebraic expressions that may be used in the evaluation of finite dose dermal absorption experiments, affording a more data-driven approach to dermal exposure assessment. Case studies are presented that demonstrate the application of these tools to the assessment of dermal absorption data. Journal of Exposure Science and Environmental Epidemiology advance online publication. [Description provided by NIOSH]
• Subjects:
  Chemistry Dermatitis Occupational Health Safety Skin
• Keywords:
  Absorption-rates Analytical-processes Author Keywords: Risk Assessment Chemical-composition Chemical-properties Chemical-reactions Dermal Load Dermatology Evaporation Exposure-levels Fractional Absorption Mathematical-models Maximum Flux Percent Absorption Skin-exposure Skin Absorption

  More +
• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Ohio ; OSHA Region 10 ; OSHA Region 5 ; OSHA Region 8 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  65-73
• Volume:
  24
• Issue:
  1
• NIOSHTIC Number:
  nn:20042703
• Citation:
  J Expo Sci Environ Epidemiol 2014 Jan-Feb; 24(1):65-73
• Contact Point Address:
  Dr. H. Frederick Frasch, Health Effects Laboratory, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  HFrasch@cdc.gov
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing ; Services
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:925426ae45f832a60d06f1887389246796a62cbb6ac5e704ee4974c3624ff1c2329490b5a23c15a3f1eceea136c34d6ae275933b8c6a71fb3bffa9ca193672b3
• Download URL:
  https://stacks.cdc.gov/view/cdc/194841/cdc_194841_DS1.pdf
• File Type:
  [PDF - 838.90 KB ]