Dermal absorption and cutaneous toxicity of metalworking fluids

Details

• Personal Author:
  Baynes RE ; Vijay V
• Description:
  Workers in the metal fabrication industry are more often exposed to MWFs and their components such as biocides via the skin that can cause harm to the skin and/ or the entire body if absorbed by the dermal route. This chapter demonstrated why MWFs are still a major occupational concern in the metal machining industry. Several of the many performance additives such as the biocides in MWFs are readily absorbed across the skin and can illicit an inflammatory response. Research in our laboratory has demonstrated that dermal absorption and cutaneous response can be modulated by the presence of other additives in the MWF formulation. Understanding how these various additives interact with each other and the skin barrier will ultimately help inform the development and risk assessment of MWF formulations that afford greater protection to workers in the metal machining industry. [Description provided by NIOSH]
• Subjects:
  Metals Metal Workers Occupational Health Risk Assessment Safety Skin Skin Absorption
• Keywords:
  Metal-industry Metal-industry-workers Metal-workers Metalworking Metalworking-fluids Metalworking-industry Risk-analysis Skin-absorption Skin-exposure Skin-irritants
• ISBN:
  9781420079173
• Publisher:
  Informa Healthcare
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  Kansas ; North Carolina ; OSHA Region 4 ; OSHA Region 6 ; OSHA Region 7 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  361-374
• Volume:
  29
• NIOSHTIC Number:
  nn:20042644
• Citation:
  Toxicology of the skin: target organ toxicology series. Monteiro-Riviere NA ed. New York: Informa Healthcare, 2010 Feb; 29:361-374
• Editor(s):
  Monteiro-Riviere NA
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  North Carolina State University, Raleigh, North Carolina
• Peer Reviewed:
  False
• Start Date:
  20000801
• Source Full Name:
  Toxicology of the skin: target organ toxicology series
• End Date:
  20150731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d8e8fd3fa065c7dee7504f46290e5ba2f12f8f18a2c35a753b71c6c5329f4a9abf65932822e5359cb47fac43694fd4eb529f2a67bf95e362c8846f970a431537
• Download URL:
  https://stacks.cdc.gov/view/cdc/194805/cdc_194805_DS1.pdf
• File Type:
  [PDF - 1.40 MB ]