Estimation of benchmark dose for micronucleus occurrence in Chinese vinyl chloride-exposed workers

Details

• Personal Author:
  Brandt-Rauf PW ; Feng N-N ; Li Y-L ; Ma X-M ; Sun Y ; Tan H-S ; Tang N-J ; Wang Q ; Xia Z-L ; Ye Y-J ; Zhou L-F ; Zhu Y-L
• Description:
  In this study, we estimated the possibility of using benchmark dose (BMD) to assess the dose-response relationship between vinyl chloride monomer (VCM) exposure and chromosome damage. A group of 317 workers occupationally exposed to vinyl chloride monomer and 166 normal, unexposed control in Shandong Province northern China were examined for chromosomal damage in peripheral blood lymphocytes (PBL) using the cytokinesis-blocked micronucleus (CB-MN) assay of DNA damage. The exposed group (3.47 + / = 2.65)(0/00) showed higher micronucleus frequency than the control (1.60 + / = 1.30)(0/00) (P < 0.01). Occupational exposure level based on micronucleus occurrence in all individuals was analyzed with benchmark dose (BMD) methods. The benchmark dose lower limit of a one-sided 95% confidence interval (BMDL) for 10% excess risk was also determined. Results showed a dose-response relationship between cumulative exposure and MN frequency, and a BMDL of 0.54 mg/m3 and 0.23 mg/m3 for males and females, respectively. Female workers were more susceptible to MN damage than male workers. [Description provided by NIOSH]
• Subjects:
  Biological Assay Blood Chlorine Chromosomes DNA Genetics Men Occupational Health Risk Assessment Risk Factors Safety Women

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• Keywords:
  Author Keywords: Vinyl Chloride Monomer Benchmark Dose Bioassays Chlorides Chromosomal Damage Chromosome-damage DNA-damage Dose-response Exposure-levels Genes Humans Lymphocytes Micronucleus Monomers Risk-factors Statistical-analysis Workers

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• ISSN:
  1438-4639
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Florida ; Illinois ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  76-81
• Volume:
  216
• Issue:
  1
• NIOSHTIC Number:
  nn:20042585
• Citation:
  Int J Hyg Environ Health 2013 Jan; 216(1):76-81
• Contact Point Address:
  Zhao-lin Xia, Department of Occupational Health and Toxicology, Box 288, School of Public Health, Fudan University, Shanghai 200032, China
• Email:
  zlxia@shmu.edu.cn
• CAS Registry Number:
  Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20010701
• Source Full Name:
  International Journal of Hygiene and Environmental Health
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5d56090ae427b11f4cc0cdcae5bef913a9ed9626738a27219b1c3ded05169044c64ef0d25dd61c0fa1dab3ab0fb0e3cdbd82f1632a57a02aec4668c2294971a7
• Download URL:
  https://stacks.cdc.gov/view/cdc/194766/cdc_194766_DS1.pdf
• File Type:
  [PDF - 254.30 KB ]