Pulmonary toxicity and fibrogenic response of carbon nanotubes

Details

• Personal Author:
  Manke A ; Rojanasakul Y ; Wang L
• Description:
  Carbon nanotubes (CNTs) have been a subject of intensive research for a wide range of applications. However, because of their extremely small size and light weight, CNTs are readily inhaled into human lungs resulting in increased rates of pulmonary disorders, most notably fibrosis. Several studies have demonstrated the fibrogenic effects of CNTs given their ability to translocate into the surrounding areas in the lung causing granulomatous lesions and interstitial and sub-pleural fibrosis. However, the mechanisms underlying the disease process remain obscure due to the lack of understanding of the cellular interactions and molecular targets involved. Interestingly, certain physicochemical properties of CNTs have been shown to affect their respiratory toxicity, thereby becoming significant determinants of fibrogenesis. CNT-induced fibrosis involves a multitude of cell types and is characterized by the early onset of inflammation, oxidative stress and accumulation of extracellular matrix. Increased reactive oxygen species activate various cytokine/growth factor signaling cascades resulting in increased expression of inflammatory and fibrotic genes. Profibrotic growth factors and cytokines contribute directly to fibroblast proliferation and collagen production. Given the role of multiple players during the pathogenesis of CNT-induced fibrosis, the objective of this review is to summarize the key findings and discuss major cellular and molecular events governing pulmonary fibrosis. We also discuss the physicochemical properties of CNTs and their effects on pulmonary toxicities as well as various biological factors contributing to the development of fibrosis. [Description provided by NIOSH]
• Subjects:
  Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Angiogenesis Epithelial Mesenchymal Transition Fibrogenesis Fibrogenicity Inflammation Lung-disease Lung-disorders Lung-fibrosis Lung Fibrosis Nanotechnology Oxidative Stress Physiological-chemistry Pulmonary-system-disorders Respiratory-system-disorders

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• ISSN:
  1537-6516
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  196-206
• Volume:
  23
• Issue:
  3
• NIOSHTIC Number:
  nn:20042417
• Citation:
  Toxicol Mech Methods 2013 Mar; 23(3):196-206
• Contact Point Address:
  Yon Rojanasakul, PhD, Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
• Email:
  yrojan@hsc.wvu.edu
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0)
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology Mechanisms and Methods
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d653927a2d71fa1aa079063fea476e38c77902f391f73f6c8bae5fedf022184b70145fa8d5034930ea2968b4e66e108087c69449a48941dc9eed7b1e6addb07f
• Download URL:
  https://stacks.cdc.gov/view/cdc/194649/cdc_194649_DS1.pdf
• File Type:
  [PDF - 536.32 KB ]