Mechanisms Underlying the Fibrogenic Responses of Carbon Nanotubes

Details

• Personal Author:
  Manke A ; Rojanasakul L ; Rojanasakul Y
• Description:
  Carbon nanotubes (CNTs) are newly developed engineered nanomaterials with remarkable properties employed for a wide range of numerous commercial and industrial applications. However, CNT exposure in various settings is a significant concern as CNTs are readily inhaled into human lungs resulting in debilitating pulmonary responses, most notably fibrosis. Several rodent studies have demonstrated consistent adverse pulmonary effects including inflammation and granulomatous lesions leading to interstitial and subpleural fibrosis. Some of the crucial mechanistic steps involved during CNT-induced fibrosis range from generation of reactive oxygen species, inflammation, release of proinflammatory cytokines that initiate several intracellular cell signaling cascades, and expansion of the pool of myofibroblast via epithelial-mesenchymal transition. Furthermore, physicochemical properties of CNT including length and surface functionalization can influence their fibrogenic activity. The objective of this chapter is to review, summarize, and discuss major cellular and molecular mechanisms driving CNT-induced fibrogenesis. [Description provided by NIOSH]
• Subjects:
  Cells, Cultured Fibrosis Immune System Lung Lung Diseases Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Carbon Nanotube Carbon Nanotubes Cell Cultures Cell Function Cell Signaling Cellular Function CNT Cytokines Employee Exposure Epithelial-mesenchymal Transition Fibroblast Fibroblasts Fibrogenesis Fibrogenicity Humans Immune Reaction Inflammation Inhalation Lung Cells Lung Fibrosis Lung Function Lung Lesions Myofibroblast Nanomaterials Nanotechnology Occupational Exposure Oxidative Stress Pulmonary System Disorders Reactive Oxygen Species Respiratory System Disorders ROS Signaling TGF-beta

  More +
• ISBN:
  9780444641991
• ISSN:
  1872-0854
• Publisher:
  Elsevier B.V.
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  North Carolina ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  47-68
• Volume:
  12
• NIOSHTIC Number:
  nn:20053138
• Citation:
  Advances in molecular toxicology. Fishbein JC, Heilman JM, eds. Cambridge, MA: Elseiver 2018 Oct; 12:47-68
• Contact Point Address:
  Yon Rojansakul, Department of Pharmaceutical Sciences, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, United States
• Email:
  yrojan@hsc.wvu.edu
• CAS Registry Number:
  Carbon nanotubes (CAS RN 308068-56-6)
• Editor(s):
  Fishbein JC; Heilman JM
• Federal Fiscal Year:
  2019
• Peer Reviewed:
  False
• Source Full Name:
  Advances in molecular toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:55a50cf54edfd69257e2cda9c059294ba566b0513fbc3818d9fa519576964e4d4c9e10871bfee08fc6158112745c037d26dd02768dc565a152dae7adae504b34
• Download URL:
  https://stacks.cdc.gov/view/cdc/215955/cdc_215955_DS1.pdf
• File Type:
  [PDF - 221.41 KB ]