Ischemic heart disease mortality and PM(3.5) in a cohort of autoworkers

Details

• Personal Author:
  Costello S ; Eisen EA ; Garcia E ; Hammond SK
• Description:
  Background: Increased risk of ischemic heart disease (IHD) has been associated with particulate matter (PM) from air pollution. Yet evidence of increased risk associated with higher workplace exposures is scant. Methods: We examined the exposure-response relationship between IHD mortality and PM(3.5) (<3.5 microm diameter) from current and cumulative exposure to straight metalworking fluid in a cohort of 39,412 autoworkers followed from 1941 to 1995. Age, calendar year of follow up, sex, race, and plant were included in each model. Results: To address the decrease in polycyclic-aromatic hydrocarbon (PAH) content in the straight metalworking fluid over time, analyses were stratified by calendar time. Increased risk of IHD mortality was associated with current exposure to PM(3.5) before 1971 and with cumulative exposure to PM(3.5) after 1971. Conclusions: Results provide modest evidence that occupational exposure to fine PM from straight fluids, especially fluid with higher PAH, may increase the risk of IHD mortality. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution, Indoor Automobiles Cardiovascular Diseases Cardiovascular System Demography Epidemiology Hydrocarbons Metals Mortality Occupational Diseases Occupational Exposure Occupational Health Particulate Matter Polycyclic Aromatic Hydrocarbons Risk Assessment Safety Staff Development

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• Keywords:
  Air-contamination Author Keywords: Epidemiology Automotive-industry Cardiovascular-disease Cardiovascular-system-disease Cardiovascular-system-disorders Cohort Study Cutting-oils Demographic-characteristics Disease-prevention Diseases Dose-response Employee-exposure Fluids Heart Heart-rate Heart Disease Metalworking-fluids Metalworking Fluid Mortality Mortality-data Mortality-rates Occupational Occupational-diseases Occupational-health Occupational-health-programs Particulate-dust Particulate Matter Particulates Polycyclic-aromatic-hydrocarbons Risk-analysis

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  317-325
• Volume:
  56
• Issue:
  3
• NIOSHTIC Number:
  nn:20042029
• Citation:
  Am J Ind Med 2013 Mar; 56(3):317-325
• Contact Point Address:
  Sadie Costello, PhD, Environmental Health Science, School of Public Health, University of California, 789 University Hall, Berkeley, CA 94720
• Email:
  sadie@berkeley.edu
• Federal Fiscal Year:
  2013
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20070801
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20100731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9fc9633631deb9ec0f56d58089cec850bb31994fabae77dc0555fd157fa1e9a973aeffbc035e45b1c6cdb0d0fa14a37638ca029e020981d00fcfdb01dd611bb9
• Download URL:
  https://stacks.cdc.gov/view/cdc/194402/cdc_194402_DS1.pdf
• File Type:
  [PDF - 238.15 KB ]