Combined effect of lung function level and decline increases morbidity and mortality risks

Details

• Personal Author:
  Baughman, Penelope ; Hnizdo, Eva ; Lange P ; Marott JL ; Martin CJ ; Petsonk, Edward L. ; Shankar A
• Description:
  Lung function level and decline are each predictive of morbidity and mortality. Evaluation of the combined effect of these measurements may help further identify high-risk groups. Using Copenhagen City Heart Study longitudinal spirometry data (n = 10,457), 16-21 year risks of chronic obstructive pulmonary disease (COPD) morbidity, COPD or coronary heart disease mortality, and all-cause mortality were estimated from combined effects of level and decline in forced expiratory volume in one second (FEV(1)). Risks were evaluated using Cox proportional hazards models for individuals grouped by combinations of baseline predicted FEV(1) and quartiles of slope. Hazard ratios (HR) and 95 % confidence intervals (CI) were estimated using stratified analysis by gender, smoking status, and baseline age (=45 and >45). For COPD morbidity, quartiles of increasing FEV(1) decline increased HRs (95 % CI) for individuals with FEV(1) at or above the lower limit of normal (LLN) but below 100 % predicted, reaching 5.11 (2.58-10.13) for males, 11.63 (4.75-28.46) for females, and 3.09 (0.88-10.86) for never smokers in the quartile of steepest decline. Significant increasing trends were also observed for mortality and in individuals with a baseline age =45. Groups with 'normal' lung function (FEV(1) at or above the LLN) but excessive declines (fourth quartile of FEV(1) slope) had significantly increased mortality risks, including never smokers and individuals with a baseline age =45. [Description provided by NIOSH]
• Subjects:
  Age Factors Cardiovascular System Epidemiology Lung Morbidity Mortality Occupational Health Respiratory Function Tests Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Sex Characteristics Smokers Tobacco Products

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• Keywords:
  Age-factors Analytical-models Author Keywords: Chronic Obstructive Pulmonary Disease Cardiopulmonary-function Cardiovascular-function Cigarette-smoking Heart Long-term-study Lung-function Morbidity-rates Mortality-rates Pulmonary-function Pulmonary-function-tests Respiratory-system-disorders Respiratory Symptoms Risk-factors Sex-factors Smoking Spirometry Surveillance

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• ISSN:
  0393-2990
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  27
• Issue:
  12
• NIOSHTIC Number:
  nn:20042004
• Citation:
  Eur J Epidemiol 2012 Dec; 27(12):933-943
• Contact Point Address:
  P. Baughman, Division of Respiratory Disease Studies, Surveillance Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV, 26505, USA
• Email:
  goz2@cdc.gov
• Federal Fiscal Year:
  2013
• Performing Organization:
  West Virginia University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  European Journal of Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e60926e9a658662122de18e257fbf474c5dfa529130fab10ea9870cb5e712b391d72ab1ace3976e401b3305a8955efcf3f881f01f81427026bf955604f8a619a
• Download URL:
  https://stacks.cdc.gov/view/cdc/194384/cdc_194384_DS1.pdf
• File Type:
  [PDF - 421.35 KB ]