Longitudinal decline in lung function in former asbestos exposed workers

Details

• Personal Author:
  Algranti E ; Bassacos MA ; De Capitani EM ; Freitas JBP ; Hnizdo, Eva ; Mendonca EMC ; Raile V
• Description:
  Background: This study was designed to assess the effect of asbestos exposure on longitudinal lung function decline. Methods: A group of 502 former asbestos-cement workers with at least two spirometry tests 4 years apart. Repeated evaluations included respiratory symptoms questionnaire, spirometry and chest imaging. Asbestos exposure was ascertained as years of exposure, an index of cumulative exposure and latency time. The mixed effects model was used to evaluate the effect of exposure on the level and rate of change in forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC). Results: Mean age at entry was 51 (SD 9.9) years, mean latency time 25.6 (SD 10.0) years, mean follow-up time 9.1 (SD 2.8) years and mean number of spirometry tests 3.5. The FEV1 level was significantly related to pack-years of smoking at entry and during the follow-up, the index of cumulative asbestos exposure at entry, and the presence of asbestosis at follow-up. The FVC level was significantly related to pack-years of smoking during the follow-up, cumulative asbestos exposure at entry, asbestosis and pleural thickening at follow-up, and body mass index at entry. Asbestos exposure was not associated with increasing rates of FEV1 and FVC decline. However, FEV1 regression slopes with age, estimated by terciles of cumulative exposure, showed significant differences. Combined effects of smoking and exposure conferred further acceleration in lung function decline. Conclusion: Occupational exposure in asbestoscement industry was a risk factor for increased lung function decline. The effect seems to be mostly concentrated during the working period. Smoking and exposure had synergic effects. [Description provided by NIOSH]
• Subjects:
  Aging Asbestos Body Weight Demography Dust Epidemiology Inorganic Chemicals Lung Lung Diseases Men Occupational Health Radiography Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smokers Surveys And Questionnaires Women

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• Keywords:
  Age-groups Asbestos-cement Asbestos-dust Asbestos-fibers Asbestosis Body-weight Chest-X-rays Demographic-characteristics Exposure-levels Humans Lung-disease Lung-fibrosis Lung-function Models Pulmonary-disorders Pulmonary-function Pulmonary-system Questionnaires Risk-factors Smoking Statistical-analysis Weight-factors Workers

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• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  15-21
• Volume:
  70
• Issue:
  1
• NIOSHTIC Number:
  nn:20041936
• Citation:
  Occup Environ Med 2013 Jan; 70(1):15-21
• Contact Point Address:
  Dr Eduardo Algranti, Division of Medicine, FUNDACENTRO DMe/CST, R. Capote Valente 710, São Paulo, 05409-002, Brazil
• Email:
  eduardo@fundacentro.gov.br
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4)
• Federal Fiscal Year:
  2013
• Peer Reviewed:
  True
• Source Full Name:
  Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:87381a319b1e8398992a81b2909e93f59477f392f7b39d81b1ebbcee02fb8db8e17afb99f44a91bf99eeae101d26fe6d999ec8f15c084e599319e555cd675387
• Download URL:
  https://stacks.cdc.gov/view/cdc/194343/cdc_194343_DS1.pdf
• File Type:
  [PDF - 144.33 KB ]