Criteria for a Recommended Standard: Occupational Exposure to Nitriles [1978]

Details

• Journal Article:
  National Institute for Occupational Safety and Health
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  NIOSH recommends in this document that worker exposure to nitriles shall not exceed the following specified limits: acetone- cyanohydrin (75865), 4mg/m3; glycolonitrile (107164), 5mg/m3; tetramethylsuccinonitrile (3333526), 6mg/m3; malononitrile (109773), 8mg/m3; propionitrile (107120), 14mg/m3; adiponitrile (111693), 18mg/m3; succinonitrile (110612), 20mg/m3; n-butyronitrile (109740), 22mg/m3; isobutyronitrile (78820), 22mg/m3; and acetonitrile (75058), 34mg/m3. Recommendations were included for environmental sampling and analysis of workplace air, medical surveillance of employees, labeling and posting, use of personal protective equipment and clothing, training of employees regarding hazardous exposures, work practices and control procedures, sanitation, monitoring and recordkeeping requirements. Effects of selected nitriles on humans include bronchial tightness, gastric distress, respiratory distress, hypotension, conjunctivitis, chest pain, skin discoloration, tachypnea, dizziness, vomiting, convulsions, coma, cyanosis, retching, thyroid reaction, duodenal ulcers, eye irritation, and muscle spasms. No reports were identified which discuss possible carcinogenic, mutagenic, or teratogenic effects of these nitriles, except adiponitrile which was tested for mutagenicity and found to lack this quality. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Cyanides Kidney Diseases Liver Manufacturing And Industrial Facilities Nervous System Nervous System Disorders Nitriles Occupational Exposure Occupational Health Petroleum Safety Solvents Urogenital Diseases Urogenital System

  More +
• Keywords:
  NIOSH-Criteria-Document; Petroleum-refineries; Chemical-industry-workers; Solvents; Central-nervous-system-disorders; Cardiovascular-system-disorders; Kidney-disorders; Liver-disorders; Cyanides
• Source:
  Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-212, 1978 Sep; :1-163
• Series:
  NIOSH Numbered Publications
• Subseries:
  Criteria Document
• DOI:
  https://doi.org/10.26616/NIOSHPUB78212
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Standards
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DCDSD - Division of Criteria Documents and Standards Developments
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  165 pdf pages
• NIOSHTIC Number:
  nn:00184106
• NTIS Accession Number:
  PB81-225534
• CAS Registry Number:
  2,2,3,3-Tetramethylbutanedinitrile (CAS RN 3333-52-6) ; Acetone cyanohydrin (CAS RN 75-86-5) ; Acetonitrile (CAS RN 75-05-8) ; Adiponitrile (CAS RN 111-69-3) ; Butyronitrile (CAS RN 109-74-0) ; Hydroxyacetonitrile (CAS RN 107-16-4) ; Isobutyronitrile (CAS RN 78-82-0) ; Malononitrile (CAS RN 109-77-3) ; Propionitrile (CAS RN 107-12-0) ; Succinonitrile (CAS RN 110-61-2)
• Federal Fiscal Year:
  1978
• Performing Organization:
  Equitable Environmental Health, Inc.
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health Guidelines and Recommendations
• Main Document Checksum:
  urn:sha-512:65d327ca3d1d55f742189d90e935e90deac7cfd60b1abd81239cf72c55589169c5c8e38075c8ff7562e59bf94c0d0fe7f17e5c0b1d15ab114c10dc1837123fdc
• Download URL:
  https://stacks.cdc.gov/view/cdc/19427/cdc_19427_DS1.pdf
• File Type:
  [PDF - 3.05 MB ]