Effect of chronic sallicylate treatment on age-related cochlear degeneration

Details

• Personal Author:
  Bielefeld E ; Chen G-D ; Henderson D ; Kermany MH ; Li M ; Salvi R ; Tanaka C
• Description:
  Salicylate (aspirin) is a widely used drug in clinics. Acute application of salicylate may cause reversible hearing loss, reduction of distortion product otoacoustic emission (DPOAE), and loss of outer hair cell (OHC) electromotility. A long-term application may cause tinnitus. Interestingly, it has been reported that a long-term salicylate application up-regulated expression of prestin, the OHC motor protein, consequently leading to an increase of OHC electromotility and DPOAE. Salicylate has also been shown to have protective effect on ototoxicity induced by noise, cisplatin and gentamicin. In the current study, aging Fischer 344 rats (18 months old) were treated with sodium salicylate at a dose of 100 mg/kg for 2 times per day for 5 days per week for 3 weeks. DPOAE and auditory brainstem response (ABR) were recorded and compared before and after the treatment. The OHC-related cochlear functions including cochlear microphonics (CM) and cochear amplification were also determined. Finally, prestin levels in OHCs were examined immunohistochemically. It appeared that the treatment delayed some aging processes. This study was supported by NIOSH grant 1R01OH008113-01A1 [Description provided by NIOSH]
• Subjects:
  Age Factors Animals Hearing Hearing Loss Hearing Loss, Noise-Induced Laboratories Noise Occupational Health Safety
• Keywords:
  Age-factors Exposure-levels Hearing-disorders Hearing-loss Laboratory-animals Molecular-structure Noise-exposure Noise-induced-hearing-loss
• ISSN:
  0742-3152
• Publisher:
  Association for Research in Otolaryngology
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Maryland ; Missouri ; New York ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  32
• NIOSHTIC Number:
  nn:20041699
• Citation:
  Abstr Midwinter Res Meet Assoc Res Otolaryngol 2009 Feb; 32:197
• Editor(s):
  Santi PA
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Manufacturing ; Wholesale and Retail Trade
• Performing Organization:
  Washington University, St. Louis
• Peer Reviewed:
  False
• Start Date:
  20000401
• Source Full Name:
  Abstracts of the 32nd Midwinter Research Meeting of the Association for Research in Otolaryngology, Febuary 14-19, 2009, Baltimore, Maryland
• End Date:
  20130914
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c5b979803353783ad1d02950d9d3da48a38111f19ed61f49215a2a5f9d94953bbba9a4b5c33439fd485b78de9e2cb99d069d72341a8364a94f948f61f73e14d4
• Download URL:
  https://stacks.cdc.gov/view/cdc/194190/cdc_194190_DS1.pdf
• File Type:
  [PDF - 235.13 KB ]