Changes in E-cadherin in the cochlea after traumatic noise exposure

Details

• Personal Author:
  Chen G-D ; Henderson D ; Hu BH ; Salvi R ; Tanaka C
• Description:
  Leonova and Raphael (1997) reported that the adhesion molecule, E-cadherin, alters distribution patterns resulting from scar tissue formation in the cochlea after administration of kanamycin. They speculated that E-cadherin may play an important role in the transmission of sound and the process of the scar tissue formation in the cochlea after ototoxic drug administration. We investigated changes in E-cadherin in the organ of Corti in rats immediately after exposure to a traumatic noise (10- 20 kHz broad band noise at 110 dB SPL for 4 hours) using a confocal microscope. Similar to the previous study (Leonova and Raphael, 1997), E-cadherin was found in the reticular lamina. However, intense E-cadherin staining that outlined the apical part of the outer hair cells (OHCs) was observed in the reticular lamina in the noise-induced damage lesion (basal turn) immediately after the noise exposure. This phenomenon was not observed in the unexposed control animals. The OHCs that showed localization of E-cadherin, were found to be apoptotic or have missing nuclei. This E-cadherin localization may be related to the mechanical stress caused by the intense noise since this phenomenon was not previously observed in the kanamycin-treated cochlea. This study was supported by NIOSH grant 1R01OH008113-01A1. [Description provided by NIOSH]
• Subjects:
  Animals Hearing Hearing Loss Hearing Loss, Noise-Induced Laboratories Noise Occupational Health Safety
• Keywords:
  Exposure-levels Hearing-disorders Hearing-loss Laboratory-animals Molecular-structure Noise-exposure Noise-induced-hearing-loss Tissue-culture
• ISSN:
  0742-3152
• Publisher:
  Association for Research in Otolaryngology
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Maryland ; Missouri ; New York ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  47
• Volume:
  32
• NIOSHTIC Number:
  nn:20041698
• Citation:
  Abstr Midwinter Res Meet Assoc Res Otolaryngol 2009 Feb; 32:47
• Editor(s):
  Santi PA
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Manufacturing ; Wholesale and Retail Trade
• Performing Organization:
  Washington University, St. Louis
• Peer Reviewed:
  False
• Start Date:
  20000401
• Source Full Name:
  Abstracts of the 32nd Midwinter Research Meeting of the Association for Research in Otolaryngology, Febuary 14-19, 2009, Baltimore, Maryland
• End Date:
  20130914
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c892b7eb995b6993b5f54d8124b449c7a61e823f82920648796b4b35626e8066c78ff2aec176943bf160436637d19936f9f840a724743b315f006922787447dd
• Download URL:
  https://stacks.cdc.gov/view/cdc/194189/cdc_194189_DS1.pdf
• File Type:
  [PDF - 235.43 KB ]