Exposure to polycyclic aromatic hydrocarbons and serum inflammatory markers of cardiovascular disease

Details

• Personal Author:
  Arheart, Kris ; Clark JD III ; Fleming, Lora E. ; Lee DJ ; Serdar B ; Wilkinson JD
• Description:
  Polycyclic aromatic hydrocarbons (PAHs) are environmental and occupational carcinogens produced by the incomplete combustion of organic materials, such as coal and petroleum product combustion, tobacco smoking, and food cooking, that may be significant contributors to the burden of cardiovascular disease in human populations. The purpose of this study was to investigate associations between ten monohydroxy urinary metabolites of four PAHs and three serum biomarkers of cardiovascular disease (fibrinogen, homocysteine, and white blood cell count). Using data on 3219 participants aged 20 years and older from the National Health and Nutrition Examination Survey (NHANES) 2001-2004 dataset, the associations between PAH metabolites and serum inflammatory markers were analyzed using the Spearman correlations and multiple linear regression modeling. The PAH metabolites of naphthalene, fluorene, phenanthrene, and pyrene each showed both positive and negative correlations with homocysteine, fibrinogen, and white blood cell count (correlation coefficient range: -0.077-0.143) in nonsmoking participants. Using multiple linear regression models adjusted for age, gender, race/ethnicity, and body mass index, estimates of weighted geometric means of inflammatory marker levels were not significantly different between high and low levels (75th vs. 25th percentiles) for all PAH metabolites in nonsmoking subjects. The results of this study do not provide evidence for a relationship between PAH exposure (as measured by urinary levels of PAH metabolites) and serum biomarkers of cardiovascular disease after controlling for tobacco use. [Description provided by NIOSH]
• Subjects:
  Aging Biomarkers Body Weight Carcinogens Cardiovascular Diseases Cardiovascular System Coal Dust Energy Metabolism Hydrocarbons Men Occupational Exposure Occupational Health Petroleum Polycyclic Aromatic Hydrocarbons Safety Smoke Tobacco Products Urine Women

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• Keywords:
  Age-groups Author Keywords: Polycyclic Aromatichydrocarbons Body-weight Cardiovascular-disease Cardiovascular-system-disease Cardiovascular-system-disorders Cardiovascular Disease Coal-dust Coal-products Combustion-products Fibrinogen Hazards Homocysteine Humans Metabolites Occupational-hazards Organic-compounds Polycyclic-aromatic-hydrocarbons Sociological-factors Tobacco-smoke Urinalysis White Bloodcells

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Florida ; OSHA Region 4 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  132-137
• Volume:
  117
• NIOSHTIC Number:
  nn:20041651
• Citation:
  Environ Res 2012 Aug; 117:132-137
• Contact Point Address:
  John D.Clark III, Department of Epidemiology and Public Health, Miller School of medicine, University of Miami, 1120 NW 14th Street, Room 1049, CRB Building (R669) Miami, FL33136
• Email:
  jclark2@med.miami.edu
• CAS Registry Number:
  Fluorene (CAS RN 86-73-7) ; Phenanthrene (CAS RN 85-01-8) ; Pyrene (CAS RN 129-00-0)
• Federal Fiscal Year:
  2012
• Performing Organization:
  University of Miami School of Medicine, Miami, Florida
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Environmental Research
• End Date:
  20120831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:33bb28b0b6cd32ae0b5c4cc27fc5e58e09b5259bbe92b97c5152d0e81e974342721a79a35d700d8c7c8e44002630cfc2163852d3e0c6dfba4c51e7b7eaf4baa2
• Download URL:
  https://stacks.cdc.gov/view/cdc/194151/cdc_194151_DS1.pdf
• File Type:
  [PDF - 147.76 KB ]