Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube-induced fibrogenic and angiogenic responses

Details

• Personal Author:
  Azad N ; Iyer AKV ; Liu Y ; Lu Y ; Rojanasakul Y ; Wang L
• Description:
  Single-walled carbon nanotubes (SWCNTs) are fibrous nanoparticles that are being used widely for various applications including drug delivery. SWCNTs are currently under special attention for possible cytotoxicity. Recent reports suggest that exposure to nanoparticles leads to pulmonary fibrosis. We report that SWCNT-mediated interplay of fibrogenic and angiogenic regulators leads to increased angiogenesis, which is a novel finding that furthers the understanding of SWCNTinduced cytotoxicity. SWCNTs induce fibrogenesis through reactive oxygen species-regulated phosphorylation of p38 mitogen-activated protein kinase (MAPK). Activation of p38 MAPK by SWCNTs led to the induction of transforming growth factor (TGF)-b1 as well as vascular endothelial growth factor (VEGF). Both TGF-b1 and VEGF contributed significantly to the fibroproliferative and collagen-inducing effects of SWCNTs. Interestingly, a positive feedback loop was observed between TGF-b1 and VEGF. This interplay of fibrogenic and angiogenic mediators led to increased angiogenesis in response to SWCNTs. Overall this study reveals key signalling molecules involved in SWCNT-induced fibrogenesis and angiogenesis. [Description provided by NIOSH]
• Subjects:
  Cytotoxins Fibrosis Growth Lung Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Angiogenesis Author Keywords: SWCNTs Cytotoxicity Exposure-levels Growth-factors Nanotechnology P38 MAPK Particulates Pulmonary-function Pulmonary-system Pulmonary-system-disorders TGF-b1 VEGF

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• ISSN:
  1743-5390
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Virginia ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  157-168
• Volume:
  7
• Issue:
  2
• NIOSHTIC Number:
  nn:20041636
• Citation:
  Nanotoxicology 2013 Mar; 7(2):157-168
• Contact Point Address:
  Neelam Azad, Department of Pharmaceutical Sciences, Hampton University, Hampton, VA 23668
• Email:
  neelam.azad@hamptonu.edu
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Nanotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a784f60cc05651fe2bafd73eb2d10cab2fdb192f25a7d2173aa0291bdfe70286c6e2ee498bf6a3e10f22803e9c5511aae7493aadc60271bb695ac5bf6c1eab7e
• Download URL:
  https://stacks.cdc.gov/view/cdc/194138/cdc_194138_DS1.pdf
• File Type:
  [PDF - 969.18 KB ]