Details:

Corporate Authors:
National Institute for Occupational Safety and Health.
Description:
"Chemical and toxicological properties, criteria, and recommended standards for ethylene-bromide (106934) (EDB) are reported. Data from human and experimental animal studies indicate that adverse effects from exposure to EDB include ocular, dermal, and respiratory irritation, and systemic effects on the liver, kidneys, spleen, cardiovascular, and central nervous systems. Dose response relationships and threshold levels have not been established; however, experimental data on animals strongly suggest that exposure to EDB can induce sterility, malformations, and hereditary damage. Carcinomas of the stomach have been produced in rats and mice administered EDB by direct intubation into the stomach. Epidemiologic evidence of adverse effects due to occupational exposure to EDB is not sufficient to identify a worker problem. However, higher death rates due to malignancies are apparent in employees having 6 or more years exposure to EDB. NIOSH recommends that the exposure limit of EDB be substantially lowered from the current federal standards of 20ppm for an 8 hour limit, 30ppm ceiling to a ceiling of 0.13ppm for any 15 minute sampling period. At this level an employee would have a maximum of about 686mg/kg for a 40 year working lifetime, which is substantially below the dose known to cause adverse effects in experimental animals. Medical surveillance should be provided for all employees working with EDB and records involving EDB exposure should be kept for 30 years after termination of employment. Recommendations are made for protective clothing and equipment to prevent dermal and ocular contact with liquid EDB. Further research is urged to provide a better scientific basis for the recommended health standards" - NIOSHTIC-2
Subject:
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Environmental Exposure
Hydrocarbons, Brominated/poisoning
Occupational Diseases/prevention & Control

Series:
Criteria for a recommended standard ; DHEW publication ; no. (NIOSH) 77-221
Criteria for a recommended standard ; DHEW publication ; no. (NIOSH) 77-221 Less -
Document Type:
Report
Funding:
NIOSH Contract 099-74-0031
Genre:
Standards
Collection(s):
Stephen B. Thacker CDC Library collection
Guidelines and Recommendations
Main Document Checksum:
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urn:sha256:55a943f4664a6ab8dd5be2314d0530b58f32a874b4c92d10490b98e0d7a8625f
File Type:

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