Residential black carbon exposure and circulating markers of systemic inflammation in elderly males: the Normative Aging Study

Details

• Personal Author:
  Alexeeff SE ; Christiani, David C. ; Coull B ; Fang SC ; Gryparis A ; Mehta AJ ; Schwartz J ; Vokonas P
• Description:
  BACKGROUND: Traffic-related particles (TRPs) are associated with adverse cardiovascular events. The exact mechanisms are unclear, but systemic inflammatory responses likely play a role. OBJECTIVES: We conducted a repeated measures study among male participants of the Normative Aging Study in the greater Boston, Massachusetts, area to determine whether individual-level residential black carbon (BC), a marker of TRPs, is associated with systemic inflammation and whether coronary heart disease (CHD), diabetes, and obesity modify associations. METHODS: We quantified markers of inflammation in 1,163 serum samples from 580 men. Exposure to BC up to 4 weeks prior was predicted from a validated spatiotemporal land-use regression model. Linear mixed effects models estimated the effects of BC on each marker while adjusting for potential confounders. RESULTS: Associations between BC and blood markers were not observed in main effects models or when stratified by obesity status. However, BC was positively associated with markers of inflammation in men with CHD (particularly vascular endothelial growth factor) and in men with diabetes (particularly interleukin-1β and tumor necrosis factor-a). Significant exposure time windows varied by marker, although in general the strongest associations were observed with moving averages of 2-7 days after a lag of several days. CONCLUSIONS: In an elderly male population, estimated BC exposures were positively associated with markers of systemic inflammation but only in men with CHD or diabetes. [Description provided by NIOSH]
• Subjects:
  Aging Biomarkers Blood Cardiovascular Diseases Cardiovascular System Hematologic Tests Men Occupational Health Particulate Matter Safety
• Keywords:
  Age-groups Author Keywords: Air Pollution Black Carbon Blood-samples Cardiovascular-disease Cardiovascular-function Cardiovascular-system-disorders Cardiovascular Disease Coronary Heart Disease Diabetes Inflammation Land-use Regression Model Particulate-dust Particulate Matter Particulates Physiological-factors Physiological-function Susceptible Traffic Weight-factors

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• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  120
• Issue:
  5
• NIOSHTIC Number:
  nn:20041369
• Citation:
  Environ Health Perspect 2012 May; 120(5):674-680
• Contact Point Address:
  S.C. Fang, 665 Huntington Ave., Building 1, Room 1411, Boston, MA 02115
• Email:
  sfang@hsph.harvard.edu
• CAS Registry Number:
  Carbon black (CAS RN 1333-86-4)
• Federal Fiscal Year:
  2012
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3004094702231f0ca92ed9e92ff8f796e0b94ed6e68d577a05da303f85cb4276d78bdf4b05c0f2e33156d4859297ed8989a2b12ddb01e12a7686d4d7a4f75520
• Download URL:
  https://stacks.cdc.gov/view/cdc/193954/cdc_193954_DS1.pdf
• File Type:
  [PDF - 347.34 KB ]