Association between maternal occupational exposure to organic solvents and congenital heart defects, National Birth Defects Prevention Study, 1997-2002

Details

• Personal Author:
  Correa A ; Desrosiers TA ; Gilboa SM ; Lawson C ; Lupo PJ ; Riehle-Colarusso TJ ; Stewart PA ; van Wijngaarden E ; Waters MA
• Corporate Authors:
  National Birth Defects Prevention Network
• Description:
  Objective: To examine the relation between congenital heart defects (CHDs) in offspring and estimated maternal occupational exposure to chlorinated solvents, aromatic solvents and Stoddard solvent during the period from 1 month before conception through the first trimester. Methods: The study population included mothers of infants with simple isolated CHDs and mothers of control infants who delivered from 1997 through 2002 and participated in the National Birth Defects Prevention Study. Two methods to assess occupational solvent exposure were employed: an expert consensus-based approach and a literature-based approach. Multiple logistic regression was used to calculate adjusted ORs and 95% CIs for the association between solvent classes and CHDs. Results: 2951 control mothers and 2047 CHD case mothers were included. Using the consensus-based approach, associations were observed for exposure to any solvent and any chlorinated solvent with perimembranous ventricular septal defects (OR 1.6, 95% CI 1.0 to 2.6 and OR 1.7, 95% CI 1.0 to 2.8, respectively). Using the literature-based approach, associations were observed for: any solvent exposure with aortic stenosis (OR 2.1, 95% CI 1.1 to 4.1) and Stoddard solvent exposure with d-transposition of the great arteries (OR 2.0, 95% CI 1.0 to 4.2), right ventricular outflow tract obstruction defects (OR 1.9, 95% CI 1.1 to 3.3) and pulmonary valve stenosis (OR 2.1, 95% CI 1.1 to 3.8). Conclusions: The authors found evidence of associations between occupational exposure to solvents and several types of CHDs. These results should be interpreted in light of the potential for misclassification of exposure. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Chlorine Chlorine Compounds Occupational Exposure Occupational Health Safety Solvents Teratogenesis Urogenital Diseases Urogenital System Women

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• Keywords:
  Birth-defects Cardiac-function Cardiovascular-disease Cardiovascular-function Cardiovascular-system Cardiovascular-system-disease Cardiovascular-system-disorders Children Chlorides Chlorine-compounds Exposure-levels Heart Humans Occupational-exposure Organic-solvents Reproductive-effects Reproductive-hazards Teratogens Teratology

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• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Kentucky ; Maryland ; Mississippi ; New York ; North Carolina ; Ohio ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; Texas ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  69
• Issue:
  9
• NIOSHTIC Number:
  nn:20041173
• Citation:
  Occup Environ Med 2012 Sep; 69(9):628-635
• Contact Point Address:
  Dr Suzanne M Gilboa, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, MS E-86, 1600 Clifton Road, Atlanta, GA 30333
• Email:
  sgilboa@cdc.gov
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c8fb0a9221f1af601a02773bba92394af525db2e39e25696db4cb16fb47a4cda271a46a847827e4a8c2980b1ce5eadf09b761e3612079a45ffddc8bb78b0c1bb
• Download URL:
  https://stacks.cdc.gov/view/cdc/193788/cdc_193788_DS1.pdf
• File Type:
  [PDF - 133.66 KB ]