Pulmonary function reductions among potentially susceptible subgroups of agricultural workers in Colorado and Nebraska

Details

• Personal Author:
  Bradford M ; Burch JB ; Clark ML ; Cranmer B ; Davidson ME ; Keefe TJ ; Koehncke N ; Mehaffy J ; Prinz L ; Reynolds SJ ; von Essen S ; Yang IV
• Description:
  OBJECTIVE: Organic dust inhalation has been associated with adverse respiratory responses among agricultural workers. We evaluated factors that may confer increased susceptibility to these health effects. METHODS: We quantified personal work shift exposures to inhalable dust, endotoxin, and its 3-hydroxy fatty acid constituents, and evaluated changes in pulmonary function among 137 grain elevator, cattle feedlot, dairy, and corn farm workers. RESULTS: Increased dust exposure was associated with work shift reductions in lung function. Although interpretation is limited because of small samples, a suggestion of stronger exposure-response relationships was observed among smokers, as well as workers reporting pesticide/herbicide application, asthma, or allergies, and those with genetic polymorphisms (TLR4) (Pinteraction = 0.05). CONCLUSIONS: A better understanding of factors leading to increased susceptibility of adverse respiratory outcomes is needed to optimize exposure reduction strategies and develop more comprehensive wellness programs. [Description provided by NIOSH]
• Subjects:
  Agriculture Dust Endotoxins Farmers Herbicides Insecticides Occupational Health Respiratory System Safety Smokers
• Keywords:
  Agricultural Workers Genetic Factors Inhalation Organic Dusts Pesticides Respirable Dust Respiratory Disorders Respiratory Irritants Smoking
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Nebraska ; OSHA Region 4 ; OSHA Region 7 ; OSHA Region 8 ; South Carolina
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  54
• Issue:
  5
• NIOSHTIC Number:
  nn:20041159
• Citation:
  J Occup Environ Med 2012 May; 54(5):632-641
• Contact Point Address:
  Stephen J. Reynolds, PhD, CIH, Fellow AIHA, 154B EHB Department of Environmental and Radiological Health Sciences, Colorado State University, 1681 Campus Delivery, Ft Collins, CO 80523
• Email:
  Stephen.Reynolds@Colostate.edu
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  Colorado State University - Ft. Collins
• Peer Reviewed:
  True
• Start Date:
  20020801
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20070731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8245bc6071ea712bb9dacb51394ad79ce8ba2535be80c5a9c40916de67da51e4686aacc4c15748e9fa2d2d89fbe0096506af325b4e98884c45b4caee2acc3d89
• Download URL:
  https://stacks.cdc.gov/view/cdc/193783/cdc_193783_DS1.pdf
• File Type:
  [PDF - 384.67 KB ]