Stem cell and benzene-induced malignancy and hematotoxicity

Details

• Personal Author:
  Bi Y ; He X ; Ma Q ; Wang L
• Description:
  The biological effect of benzene on the hematopoietic system has been known for over a century. The rapid advancement in understanding the biology of hematopoietic stem cells (HSCs) and cancer stem cells (CSCs) in recent years has renewed interest in investigating the role of stem cells in benzene-induced malignancy and bone marrow depression. The interplay between benzene and stem cells is complex involving the stem cell, progenitor, and HSC niche compartments of the bone marrow. In this prospect, benzene metabolites formed through metabolism in the liver and bone marrow cause damage in hematopoietic cells via multiple mechanisms that, in addition to traditionally recognized chromosomal aberration and covalent binding, incorporate oxidative stress, alteration of gene expression, apoptosis, error-prone DNA repair, epigenetic regulation, and disruption of tumor surveillance. However, benzene-exposed individuals exhibit variable susceptibility to benzene effect that arises, in part, from genetic variations in benzene metabolism, DNA repair, genomic stability, and immune function. These new studies of benzene leukemogenesis and hematotoxicity are expected to provide insights into how environmental and occupational chemicals affect stem cells to cause cancer and toxicity, which impact the risk assessment, permissible level, and therapy of benzene exposure. [Description provided by NIOSH]
• Subjects:
  Benzene Blood Chromosomes Genetics Hematopoietic System Immune System Musculoskeletal System Neoplasms Occupational Health Safety
• Keywords:
  Benzenes Biological-effects Bone-marrow Cancer Cell-biology Cell-function Cellular-function Chromosome-damage Genes Hematopoietic-system Immune-reaction Leukemogenesis Liver Malignancy Surveillance-programs Tumors

  More +
• ISSN:
  0893-228X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  25
• Issue:
  7
• NIOSHTIC Number:
  nn:20041132
• Citation:
  Chem Res Toxicol 2012 Jul; 25(7):1303-1315
• Contact Point Address:
  Qiang Ma, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mail Stop 3014, Morgantown, West Virginia 26505
• Email:
  qam1@cdc.gov
• CAS Registry Number:
  Benzene (CAS RN 71-43-2)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Chemical Research in Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:71d2d92ae37d7cdcb29cdbaf41b5b707b68ee9fefced106ea662cc093358dddba50c61d299108ee921d08c4cab2c972eddf539522fa5f31f111a98f7a6ce14a4
• Download URL:
  https://stacks.cdc.gov/view/cdc/193767/cdc_193767_DS1.pdf
• File Type:
  [PDF - 950.16 KB ]