Induction of CYP4F3 in White Blood Cells from Benzene-Poisoning Patients and Human HL60 Cells

Details

• Personal Author:
  Bi Y ; He X ; Li L ; Ma Q ; Mao Z ; Tao N ; Xia Y ; Zhao Z
• Description:
  Exposure to benzene elicits a range of hematotoxicity from leukopenia to leukemia. We used microarray to analyze differential gene expression in the white blood cells (WBC) from 7 patients diagnosed with occupational benzene poisoning compared with 7 matched controls. All patients exhibited elevated expression of CYP4F3, a leukotriene B4 (LTB4) omega-hydroxylase critical in the inactivation of LTB4 in polymorphonuclear leukocytes (PMN), with the fold of induction between 3 and 71. CYP4F3 was also induced in cultured promyolocytic leukemia cells (HL-60) by a benzene metabolite, phenol, similarly to all-trans retinoic acid (ATRA). Induction of CYP4F3 may playa role in benzene hematotoxicity and serve as a biomarker of benzene exposure and toxicity. [Description provided by NIOSH]
• Subjects:
  Benzene Biomarkers Hematologic Diseases Hematopoietic System Occupational Health Poisoning Safety Solvents
• Keywords:
  Benzene-poisoning Benzenes Blood-disorders Hematopoietic-system
• Publisher:
  Medimond S.r.l.
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  103-107
• NIOSHTIC Number:
  nn:20034765
• Citation:
  17th International Symposium on Microsomes and Drug Oxidations, July 6-10, 2008, Saratoga Springs, New York. Kaminsky LS, ed. Bologna, Italy: Medimond S.r.l., 2008 Jul; :103-107
• CAS Registry Number:
  Benzene (CAS RN 71-43-2)
• Editor(s):
  Kaminsky LS
• Federal Fiscal Year:
  2008
• Peer Reviewed:
  False
• Source Full Name:
  17th International Symposium on Microsomes and Drug Oxidations, July 6-10, 2008, Saratoga Springs, New York
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c948e14b1a1e5d094230730116b006eefb8515b9604cadb025ef248182f4020cf93a874dd85de624fcd544bf768717df981bcc5afbc1e352fa40b377d0c7f0d1
• Download URL:
  https://stacks.cdc.gov/view/cdc/186858/cdc_186858_DS1.pdf
• File Type:
  [PDF - 650.48 KB ]