Nanoparticulate pathology

Details

• Personal Author:
  Battelli LA ; Castranova, Vincent ; Hubbs, Ann F. ; Mercer RR ; Porter, Dale ; Sargent L ; Sriram K
• Description:
  Carbon is a basic building block of life and is the major component of many compounds commonly used in our society, including carbon black and graphite. Surprisingly, new forms of carbon were discovered in the 1980s and 1990s. The carbon molecules were connected by single and double bonds and arranged into hexagonal and pentagonal rings which formed the convex three dimensional structures known as buckminsterfullerene (buckyballs) and carbon nanotubes. The discovery of fullerenes led to the 1996 Nobel Prize in chemistry and played a major role in enabling three dimensional engineering at a molecular level. The resulting new field is nanotechnology, the technology used to synthesize particulates with at least one dimension less than 100 nm. Nanotechnology is currently a multi-billion dollar industry with growth potential. Some of the promising new nanotechnology products include pharmaceuticals and medical devices engineered, or containing components which are engineered, in nanoscale dimensions, so that they may deliver improved therapies to patients. Assuring these improved therapies do not convey undo risks to patients clearly involves understanding the potential hazards of engineered nanoparticulates (NPs). In addition, the products of nanotechnology have the potential to expose the workers who produce them, researchers who study them, and the general public to newly designed structures that will often be unseen by the unaided eye. For toxicologic pathologists, nanotechnology also presents new challenges and amazing opportunities. [Description provided by NIOSH]
• Subjects:
  Biopharmaceutics Chemistry Occupational Health Particulate Matter Pathology Safety Toxicology
• Keywords:
  Chemical-properties Medical-sciences Molecular-structure Nanotechnology Particulates Pharmaceuticals Therapeutic-agents
• Publisher:
  American College of Veterinary Pathologists
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; Tennessee ; West Virginia ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-9
• NIOSHTIC Number:
  nn:20041104
• Citation:
  62nd Annual Meeting of the American College of Veterinary Pathologists and 46th Annual Meeting of the American Society for Veterinary Clinical Pathology, Proceeding of the ACVP/ASVCP Concurrent Annual Meetings, December 3-7, 2011, Nashville, Tennessee. Madison, WI: American College of Veterinary Pathologists, 2011 Dec; :1-9
• Contact Point Address:
  Ann F. Hubbs, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV
• Email:
  ahubbs@cdc.gov
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0) ; Carbon black (CAS RN 1333-86-4) ; Graphite (CAS RN 7782-42-5)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  62nd Annual Meeting of the American College of Veterinary Pathologists and 46th Annual Meeting of the American Society for Veterinary Clinical Pathology, Proceeding of the ACVP/ASVCP Concurrent Annual Meetings, December 3-7, 2011, Nashville, Tennessee
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7039174873fc8b4742761bd959565b11ccebee4ef0623845fe81731ebaf47d83926674dc5aaca5ac1c84f0960a6db6860c5e7fe2893678e27e133b67dc72862d
• Download URL:
  https://stacks.cdc.gov/view/cdc/193748/cdc_193748_DS1.pdf
• File Type:
  [PDF - 100.75 KB ]