Responses to pulmonary exposure to carbon nanotubes

Details

• Personal Author:
  Castranova, Vincent ; Mercer RR
• Description:
  In general, pulmonary exposure of rats or mice by intratracheal instillation, pharyngeal aspiration, or inhalation of SWCNT or MWCNT results in transient inflammation and lung damage. Granulomatous lesions and interstitial fibrosis, which are of rapid onset and persistent in nature, have also been a common report. The presence (raw) or absence (purified) of catalytic metals does not appear to greatly affect pulmonary response. The degree of agglomeration does affect deposition site and response. Large agglomerates tend to deposit at the terminal bronchioles and proximal alveoli and induce a granulomatous response, while more dispersed structures can deposit in the distal alveoli and cause interstitial fibrosis. The lung may be exposed to more dispersed CNT structures by inhalation than by exposure to a suspension of CNT. When this is the case, the response to short-term inhalation is often greater than that for the same lung burden given as a bolus dose. Pulmonary exposure to CNT has also been shown to cause changes in cardiovascular and central nervous system function . Mechanisms, such as inflammatory signals or neurogenic pathways, causing these systemic responses to pulmonary CNT exposure are under investigation. In light of the pulmonary and systemic responses reported in rodent studies, it appears prudent to minimize worker exposure to CNT. Normal industrial hygiene practices, i.e. containment, ventilation, and personal protective equipment, appear effective in controlling exposure [Description provided by NIOSH]
• Subjects:
  Animals Cardiovascular Diseases Cardiovascular System Fibrosis Inhalation Exposure Laboratories Lung Lung Diseases Metals Neoplasms Occupational Health Personal Protective Equipment Respiratory Protective Devices Respiratory System Respiratory Tract Diseases Safety Ventilation

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• Keywords:
  Alveolar-cells Bronchial-cancer Cancer Cardiopulmonary-function Cardiopulmonary-system Cardiopulmonary-system-disorders Cardiovascular-system Cardiovascular-system-disease Cardiovascular-system-disorders Exposure-levels Industrial-hygiene Inhalants Laboratory-animals Lung-disorders Lung-function Nanotechnology Personal-protective-equipment Pulmonary-function Pulmonary-system Pulmonary-system-disorders Respiratory-protective-equipment Respiratory-system-disorders

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• ISBN:
  9781107008373
• Publisher:
  Cambridge University Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  North Carolina ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  133-149
• NIOSHTIC Number:
  nn:20041101
• Citation:
  The toxicology of carbon nanotubes. Donaldson K, Poland CA, Duffrin R, Bonner J, eds., New York: Cambridge University Press, 2012 Jun; :133-149
• Editor(s):
  Donaldson K; Poland CA; Duffin R; Bonner J
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  The toxicology of carbon nanotubes
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2924f933f67f5d0ba0d305bd87b9023dbf4c0a10b6292d7370466a7d335accd9ab229f6cdfeb6b30e51b3b681a0e2368fcaeff2ebe57cca4e648cde3e58ec5ba
• Download URL:
  https://stacks.cdc.gov/view/cdc/193745/cdc_193745_DS1.pdf
• File Type:
  [PDF - 9.04 MB ]