An exposure-response analysis of respiratory disease risk associated with occupational exposure to chrysotile asbestos

Details

• Personal Author:
  Bailer AJ ; Brown D ; Dement, John M. ; Gilbert S ; Lemen R ; Smith R ; Stayner L ; Steenland, Kyle
• Description:
  The results from these analyses clearly demonstrate a strong exposure-response relationship between chrysotile exposure and mortality from asbestosis and lung cancer, which is not surprising given the results from previous studies. The exposure-response relationship for lung cancer appeared to be linear on a multiplicative scale, whereas the exposure-response relationship for asbestosis appeared to be sub-linear. There was no statistical evidence for a threshold in either the lung cancer or asbestosis model. Thus the results from this analysis fail to provide any support for arguments that have been made for a threshold for the effects of chrysotile asbestos on lung cancer and asbestosis risks (Browne, 1986). Based on this analysis, the predictions of excess lifetime risk for white males exposed for 45 years at the recently revised OSHA standard of 0.1 fibers cc--1 was predicted to be approximately 5 per 1000 for lung cancer and 2 per 1000 for asbestosis. The lung cancer risks estimated in this analysis were substantially higher than what was observed in previous analyses of Quebec chrysotile miners and millers (McDonald et al., 1980, 1994). The reasons for these widely varying results are not known. [Description provided by NIOSH]
• Subjects:
  Asbestos Inorganic Chemicals Lung Lung Diseases Manufacturing And Industrial Facilities Mortality Neoplasms Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Asbestos-fibers Asbestos-workers Dose-response Industrial-factory-workers Lung-cancer Mortality-data Occupational-exposure Respiratory-system-disorders
• ISSN:
  0003-4878
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; OD - Office of the Director
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  137-141
• Volume:
  41
• NIOSHTIC Number:
  nn:20040999
• Citation:
  Ann Occup Hyg, Inhaled Particles VIII 1997 Jan; 41(Suppl 1):137-141
• Federal Fiscal Year:
  1997
• Peer Reviewed:
  True
• Source Full Name:
  Annals of Occupational Hygiene, Inhaled Particles VIII
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3a8a95cd10367835a0866eb20abeef470079b42459d37a9ead35c775d9e455a1501c1ff6e34ac4efe25bdfabd50861d5b03dbaa878fcec230167245bb2a2ed61
• Download URL:
  https://stacks.cdc.gov/view/cdc/193677/cdc_193677_DS1.pdf
• File Type:
  [PDF - 278.85 KB ]