Polymorphisms in the CD14 gene associated with pulmonary function in farmers

Details

• Personal Author:
  Lambert GP ; LeVan TD ; Martinez FD ; Merchant, James A. ; Romberger DJ ; Vasquez MM ; Von Essen, Susanna
• Description:
  RATIONALE AND OBJECTIVES: Farmers experience airway obstruction, which may be attributable in part to endotoxin inhalation. CD14 is a receptor for endotoxin. MATERIALS AND METHODS: Based on our findings of increased circulating CD14 associated with the CD14/-159 T allele, we hypothesized that carriers of this allele would have decreased lung function among endotoxin-exposed individuals. CD14/-159TT farmers (n = 19) had significantly lower lung function as measured by FEV1 (p = 0.028) and mean forced expiratory flow during the middle half of the FVC (FEF25-75) (p = 0.05) compared with farmers with the C allele (n = 78). Also, farmers with the CD14/-1619GG genotype (n =11) were associated with lower lung function (FEV1, p = 0.008; FEF25-75, p = 0.009) compared with farmers with the A allele (n = 86). RESULTS: No association between CD14/-550 and lung function was observed (FEV1, p = 0.32; FEF25-75, p = 0.11). Increased prevalence of wheezing was reported in farmers homozygous for CD14/-159T (p = 0.013) or CD14/-1619G (p = 0.019) compared with farmers with the CC or AA genotype, respectively. No association was found between TLR4/Asp299Gly and lung function or wheeze. CONCLUSION: We conclude that the CD14/-159 or CD14/-1619 loci may play a role in modulating lung function and wheeze among agricultural workers. [Description provided by NIOSH]
• Subjects:
  Endotoxins Farmers Lung Lung Diseases Men Occupational Health Respiratory System Respiratory Tract Diseases Safety Women
• Keywords:
  Author Keywords: Endotoxin Farming Humans Lipopolysaccharide Lung-disorders Lung-function Occupational Exposure Pulmonary-disorders Pulmonary-function Pulmonary-system Respiration Respiratory-system-disorders Wheeze

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• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  171
• Issue:
  7
• NIOSHTIC Number:
  nn:20040809
• Citation:
  Am J Respir Crit Care Med 2005 Apr; 171(7):773-779
• Contact Point Address:
  Susanna Von Essen, M.D., M.P.H., Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska, Omaha, NE 68198-5300
• Email:
  svonesse@unmc.edu
• Federal Fiscal Year:
  2005
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:852eb55ff869b354424892c012389a5b388f2f36ebb766cc90d8acb6b1475621a311e7bce115ba86118ef0ccbd2cc7562e89a153a846e47031ec5473800e4de6
• Download URL:
  https://stacks.cdc.gov/view/cdc/193541/cdc_193541_DS1.pdf
• File Type:
  [PDF - 191.53 KB ]