Lung cancer mortality in North Carolina and South Carolina chrysotile asbestos textile workers

Details

• Personal Author:
  Dement, John M. ; Elliott L ; Hein, Misty J. ; Loomis D ; Richardson D ; Stayner L
• Description:
  Objectives: Studies of workers in two US cohorts of asbestos textile workers exposed to chrysotile (North Carolina (NC) and South Carolina (SC)) found increasing risk of lung cancer mortality with cumulative fibre exposure. However, the risk appeared to increase more steeply in SC, possibly due to differences in study methods. The authors conducted pooled analyses of the cohorts and investigated the exposure-disease relationship using uniform cohort inclusion criteria and statistical methods. Methods: Workers were included after 30 days of employment in a production job during qualifying years, and vital status ascertained through 2003 (2001 for SC). Poisson regression was used to estimate the exposure-response relationship between asbestos and lung cancer, using both exponential and linear relative rate models adjusted for age, sex, race, birth cohort and decade of follow-up. Results: The cohort included 6,136 workers, contributing 218,631 person-years of observation and 3,356 deaths. Cumulative exposures at the four study facilities varied considerably. The pooled relative rate for lung cancer, comparing 100 f-yr/ml to 0 f-yr/ml, was 1.11 (95% CI 1.06 to 1.16) for the combined cohort, with different effects in the NC cohort (RR = 1.10, 95% CI 1.03 to 1.16) and the SC cohort (RR = 1.67, 95% CI 1.44 to 1.93). Conclusions: Increased rates of lung cancer were significantly associated with cumulative fibre exposure overall and in both the Carolina asbestos-textile cohorts. Previously reported differences in exposure-response between the cohorts do not appear to be related to inclusion criteria or analytical methods. [Description provided by NIOSH]
• Subjects:
  Asbestos Demography Environmental Monitoring Inorganic Chemicals Lung Lung Diseases Mortality Neoplasms Occupational Exposure Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Risk Assessment Safety Textile Industry

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• Keywords:
  Asbestos-fibers Cancer Demographic-characteristics Dose-response Employee-exposure Exposure-assessment Fibrous-bodies Lung-cancer Mathematical-models Mortality-data Mortality-rates Risk-analysis Statistical-analysis Surveillance-programs Textile-workers Textiles Textiles-industry

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• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Nebraska ; North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  385-390
• Volume:
  69
• Issue:
  6
• NIOSHTIC Number:
  nn:20040756
• Citation:
  Occup Environ Med 2012 Jun; 69(6):385-390
• Contact Point Address:
  Dr Leslie Elliott, 984395 Nebraska Medical Center, Omaha, NE 68198-4395, USA
• Email:
  leslie.elliott@unmc.edu
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Chrysotile (CAS RN 12001-29-5)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of North Carolina, Chapel Hill
• Peer Reviewed:
  True
• Start Date:
  20030930
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20110131
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:71915f1bb19e76c341b3e155029525cd7966aba3752b2fa52be58a36c7ad650f0b123bdd006f6febf3f4b4252b7ad6885d961ccc653447778152f478bff7964b
• Download URL:
  https://stacks.cdc.gov/view/cdc/193510/cdc_193510_DS1.pdf
• File Type:
  [PDF - 168.42 KB ]