Maternal occupational exposure to organic solvents during early pregnancy and risks of neural tube defects and orofacial clefts

Details

• Personal Author:
  Correa A ; Daniels JL ; Desrosiers TA ; Langlois PH ; Lawson, Christina C. ; Meyer RE ; Olshan A ; Richardson DB ; Romitti PA ; van Wijngaarden E ; Waters MA
• Corporate Authors:
  National Birth Defects Prevention Network
• Description:
  Objectives: Though toxicological experiments demonstrate the teratogenicity of organic solvents in animal models, epidemiologic studies have reported inconsistent results. Using data from the population-based National Birth Defects Prevention Study, the authors examined the relation between maternal occupational exposure to aromatic solvents, chlorinated solvents and Stoddard solvent during early pregnancy and neural tube defects (NTDs) and orofacial clefts (OFCs). Methods: Cases of NTDs (anencephaly, spina bifida and encephalocoele) and OFCs (cleft lip 6 cleft palate and cleft palate alone) delivered between 1997 and 2002 were identified by birth defect surveillance registries in eight states; non-malformed control infants were selected using birth certificates or hospital records. Maternal solvent exposure was estimated by industrial hygienist review of self-reported occupational histories in combination with a literature-derived exposure database. ORs and 95% CIs for the association between solvent class and each birth defect group and component phenotype were estimated using multivariable logistic regression, adjusting for maternal age, race/ethnicity, education, pre-pregnancy body mass index, folic acid supplement use and smoking. Results: The prevalence of exposure to any solvent among mothers of NTD cases (n=511), OFC cases (n=1163) and controls (n=2977) was 13.1%, 9.6% and 8.2%, respectively. Exposure to chlorinated solvents was associated with increased odds of NTDs (OR=1.96, CI 1.34 to 2.87), especially spina bifida (OR=2.26, CI 1.44 to 3.53). No solvent class was strongly associated with OFCs in these data. Conclusions: The findings suggest that maternal occupational exposure to chlorinated solvents during early pregnancy is positively associated with the prevalence of NTDs in offspring. [Description provided by NIOSH]
• Subjects:
  Chlorine Compounds Demography Epidemiology Nervous System Nervous System Disorders Occupational Health Pregnancy Safety Solvents Urogenital Diseases Urogenital System Women

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• Keywords:
  Birth-defects Central-nervous-system Central-nervous-system-disorders Children Chlorine-compounds Demographic-characteristics Information-retrieval-systems Mathematical-models Nerve-function Nerves Oral-disorders Organic-compounds Organic-solvents Prenatal-exposure Reproductive-hazards Spinal-cord Statistical-analysis Surveillance-programs

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• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Iowa ; New York ; North Carolina ; Ohio ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 7 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  493-499
• Volume:
  69
• Issue:
  7
• NIOSHTIC Number:
  nn:20040754
• Citation:
  Occup Environ Med 2012 Jul; 69(7):493-499
• Contact Point Address:
  Dr. Tania A Desrosiers, Department of Epidemiology, Campus Box 7435, University of North Carolina, Chapel Hill, NC 27599, USA
• Email:
  ta_desrosiers@unc.edu
• CAS Registry Number:
  Stoddard solvent (CAS RN 8052-41-3)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cb2f971a60a313388ae637a27071b19a765463950622728a19380f11fe63c8e3b5dc78c6c64c7d3a80c6e46e772043d96f123b87c47d7ce5d5e53dc21410239e
• Download URL:
  https://stacks.cdc.gov/view/cdc/193508/cdc_193508_DS1.pdf
• File Type:
  [PDF - 112.01 KB ]