Maternal periconceptional occupational pesticide exposure and neural tube defects

Details

• Personal Author:
  Bell EM ; Burns TL ; Lawson, Christina C. ; Lin S ; Makelarski JA ; Olney RS ; Rocheleau CM ; Romitti PA ; Shaw GM ; Stewart PA ; Waters MA
• Corporate Authors:
  National Birth Defects Prevention Network
• Description:
  Background: Adverse associations between maternal pesticide exposure and neural tube defects (NTDs) have been suggested but not consistently observed. This study used data from the multisite National Birth Defects Prevention Study to examine associations between maternal periconceptional (1 month preconception through 2 months postconception) occupational pesticide exposure and NTDs. Methods: Mothers of 502 NTD cases and 2950 unaffected live-born control infants with estimated delivery dates from 1997 through 2002 were included. Duration, categorical intensity scores, and categorical frequency scores for pesticide classes (e.g., insecticides) were assigned using a modified, literature-based job-exposure matrix and maternal-reported occupational histories. Adjusted odds ratios (aORs) and 95% confidence intervals were estimated based on fitted multivariable logistic regression models that described associations between maternal periconceptional occupational pesticide exposure and NTDs. The aORs were estimated for pesticide exposure (any [yes/no] and cumulative exposure [intensity x frequency x duration] to any pesticide class, each pesticide class, or combination of pesticide classes) and all NTD cases combined and NTD subtypes. Results: Positive, but marginally significant or nonsignificant, aORs were observed for exposure to insecticides + herbicides for all NTD cases combined and for spina bifida alone. Similarly, positive aORs were observed for any exposure and cumulative exposure to insecticides + herbicides + fungicides and anencephaly alone and encephalocele alone. All other aORs were near unity. Conclusion: Pesticide exposure associations varied by NTD subtype and pesticide class. Several aORs were increased, but not significantly. Future work should continue to examine associations between pesticide classes and NTD subtypes using a detailed occupational pesticide exposure assessment and examine pesticide exposures outside the workplace. [Description provided by NIOSH]
• Subjects:
  Fungi Fungicide, Industrial Herbicides Insecticides Nervous System Nervous System Disorders Occupational Exposure Occupational Health Pregnancy Safety Teratogenesis Urogenital System Women

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• Keywords:
  Analytical-processes Author Keywords: Birth Defects Birth-defects Central-nervous-system-disorders Children Employee-exposure Encephalopathy Fungicides Mathematical-models Neural Tube Defects Occupational-exposure Occupational Exposure Pesticides Reproductive-effects Reproductive-system Spinal-cord-disorders Statistical-analysis Teratogens Teratology

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• ISSN:
  1542-0752
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  California ; Georgia ; Iowa ; New York ; Ohio ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 7 ; OSHA Region 9 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  100
• Issue:
  11
• NIOSHTIC Number:
  nn:20045386
• Citation:
  Birth Defects Res A Clin Mol Teratol 2014 Nov; 100(11):877-886
• Contact Point Address:
  Paul A. Romitti, The University of Iowa, S416 CPHB, 145 N Riverside Drive, Iowa City, IA 52242
• Email:
  paul-romitti@uiowa.edu
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  Battelle
• Peer Reviewed:
  True
• Source Full Name:
  Birth Defects Research Part A: Clinical and Molecular Teratology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:00b8e44ede7f450ac846574a78d8449e88ac76e259f79f1d7dfd57419f451dac558cfcb37a620c0757a4fff4d26cac4ce146ef8fd2a72ee91c0f898ec2bbdca1
• Download URL:
  https://stacks.cdc.gov/view/cdc/200826/cdc_200826_DS1.pdf
• File Type:
  [PDF - 117.65 KB ]