Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress

Details

• Personal Author:
  Fadeel B ; Kagan VE ; Pietroiusti A ; Shvedova AA
• Description:
  Nanotechnologies are emerging as highly promising technologies in many sectors in the society. However, the increasing use of engineered nanomaterials also raises concerns about inadvertent exposure to these materials and the potential for adverse effects on human health and the environment. Despite several years of intensive investigations, a common paradigm for the understanding of nanoparticle-induced toxicity remains to be firmly established. Here, the so-called oxidative stress paradigm is scrutinized. Does oxidative stress represent a secondary event resulting inevitably from disruption of biochemical processes and the demise of the cell, or a specific, non-random event that plays a role in the induction of cellular damage e.g. apoptosis? The answer to this question will have important ramifications for the development of strategies for mitigation of adverse effects of nanoparticles. Recent examples of global lipidomics studies of nanoparticle-induced tissue damage are discussed along with proteomics and transcriptomics approaches to achieve a comprehensive understanding of the complex and interrelated molecular changes in cells and tissues exposed to nanoparticles. We also discuss instances of non-oxidative stress-mediated cellular damage resulting from direct physical interference of nanomaterials with cellular structures. [Description provided by NIOSH]
• Subjects:
  Biochemistry Environmental Monitoring Hazardous Substances Occupational Health Safety
• Keywords:
  Apoptosis Author Keywords: Carbon Nanotubes Biochemical-analysis Biochemical-indicators Cell-alteration Cell-damage Cellular-function Cellular-reactions Cellular-structures Exposure-assessment Hazardous-materials Molecular-biology Molecular-structure Nanotechnology Oxidation Oxidative-processes Oxidative Lipidomics Oxidative Stress Proteomics Tissue-disorders Toxic-materials Transcriptomics

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• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  121-133
• Volume:
  261
• Issue:
  2
• NIOSHTIC Number:
  nn:20040727
• Citation:
  Toxicol Appl Pharmacol 2012 Jun; 261(2):121-133
• Contact Point Address:
  Anna A. Shvedova, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505
• Email:
  ats1@cdc.gov
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:66fa1b35780aee8e197e90dfd4cbb54cc9a752752eb91f3db7952611df0937a14d3e2355e4281ef4078332da39eb7b128ab16807532219983a24ef4fef6e1bf2
• Download URL:
  https://stacks.cdc.gov/view/cdc/193490/cdc_193490_DS1.pdf
• File Type:
  [PDF - 1.54 MB ]