Serum persistent organic pollutants and duration of lactation among Mexican-American women

Details

• Personal Author:
  Barr DB ; Bradman A ; Davis MD ; Eskenazi B ; Fenster-L ; Harley KG ; Holland N ; Hubbard A ; Webster M ; Weldon RH
• Description:
  BACKGROUND: Research suggests that estrogenic endocrine-disrupting chemicals interfere with lactation. OBJECTIVES: (1) to determine if estrogenic persistent organic pollutants (POPs) are associated with shortened lactation duration; (2) to determine whether previous breastfeeding history biases associations. METHODS AND RESULTS: We measured selected organochlorines and polychlorinated biphenyls (p, p'-DDE, p, p'-DDT, o, p'-DDT, beta-hexachlorocyclohexane, hexachlorobenzene, and PCBs 44, 49, 52, 118, 138, 153, and 180) in serum from 366 low-income, Mexican-American pregnant women living in an agricultural region of California and assessed breastfeeding duration by questionnaires. We found no association between DDE, DDT, or estrogenic POPs with shortened lactation duration, but rather associations for two potentially estrogenic POPs with lengthened lactation duration arose (HR [95% CI]: 0.6 [0.4, 0.8] for p, p'-DDE & 0.8 [0.6, 1.0] for PCB 52). Associations between antiestrogenic POPs (PCBs 138 and 180) and shortened lactation duration were attributed to a lactation history bias. CONCLUSION: Estrogenic POPs were not associated with shortened lactation duration, but may be associated with longer lactation duration. [Description provided by NIOSH]
• Subjects:
  Agriculture Chlorine Compounds Endocrine System Environmental Exposure Environmental Pollution Estrogens Occupational Health Polychlorinated Biphenyls Safety Surveys And Questionnaires Women

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• Keywords:
  Agricultural-workers Endocrine-function Endocrine-system Environmental-contamination Environmental-exposure Environmental-pollution Estrogenic-hormones Lactation Organic-chemicals Organic-compounds Organo-chlorine-compounds Polychlorinated-biphenyls Questionnaires

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• ISSN:
  1687-9805
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Georgia ; OSHA Region 4 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2010
• NIOSHTIC Number:
  nn:20040675
• Citation:
  J Environ Public Health 2010 Jun; 2010:861757
• Contact Point Address:
  Brenda Eskenazi, Center for Children's Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94704, USA
• Email:
  eskenazi@berkeley.edu
• CAS Registry Number:
  1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3) ; DDT (CAS RN 50-29-3) ; Hexachlorobenzene (CAS RN 118-74-1) ; β-Hexachlorocyclohexane (CAS RN 319-85-7)
• Federal Fiscal Year:
  2010
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Journal of Environmental and Public Health
• End Date:
  20060929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:97fe373b5803e1c2e178167438296f0ba32408083a8a229324c90cbfa84740098b3d57e4479656cfa690b769f3d885ca724c78f1229bf1042c435e36405a0bda
• Download URL:
  https://stacks.cdc.gov/view/cdc/193464/cdc_193464_DS1.pdf
• File Type:
  [PDF - 513.71 KB ]