Pulmonary inhalation of ultrafine TiO2 and cardiovascular effects: a neuronregulated pathway

Details

• Personal Author:
  Castranova, Vincent ; Chen BT ; Cumpston JL ; Kan H ; Kashon ML ; Lin Y ; Munson AE ; Wu Z
• Description:
  Inhalation of nano-sized air pollutant particles is a recognized risk factor for cardiovascular disease; however, the link between occupational nanoparticle exposure and adverse cardiovascular events remains unclear. We reported previously that pulmonary exposure of rats to ultrafine titanium dioxide (UFTiO2) enhances substance P synthesis in nodose ganglia, which was associated with an increased phosphorylation level of cardiac proteins. In the present study, we further investigated changes in cardiovascular function following pulmonary exposure to UFTiO2. Our study indicates that pulmonary exposure of rats to UFTiO2 (6 mg/m3) for 4 hours significantly increased heart rate and depressed diastolic function of the heart in response to isoproterenol. On the vascular side, pulmonary exposure to UFTiO2 elevated mean and diastolic blood pressure in response to norepinephrine. Pretreatment of the rats ip with the transient receptor potential (TRP) channel blocker, ruthenium red (2.5 mg/kg), not only inhibited substance P synthesis in nodose ganglia and the increased phosphorylation level in cardiac proteins, but also prevented the above cardiovascular changes induced by pulmonary exposure to UFTiO2. Our results suggest that the effects of pulmonary exposure to UFTiO2 on the cardiovascular system are most likely influenced by a lung-nodose gangliaregulated pathway via the activation of TRP channels located on the endings of c fiber sensory neurons in the lung. Activation of this neuronal pathway may contribute to an increased incidence of cardiovascular diseases associated with pulmonary inhalation of small-sized particle components from ambient air. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Environmental Monitoring Immune System Laboratories Lung Occupational Health Particulate Matter Respiratory System Safety
• Keywords:
  Cardiovascular-disease Cardiovascular-function Cardiovascular-system Cardiovascular-system-disease Dose-response Exposure-assessment Exposure-levels Exposure-methods Heart Immune-reaction Laboratory-animals Laboratory-techniques Laboratory-testing Nanotechnology Particulates Pulmonary-system

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  322-323
• Volume:
  126
• NIOSHTIC Number:
  nn:20040583
• Citation:
  Toxicologist 2012 Mar; 126(Suppl 1):322-323
• CAS Registry Number:
  Titania (CAS RN 13463-67-7)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Construction
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 51st Annual Meeting and ToxExpo, March 11-15, 2012, San Francisco, California
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:da7576af1b600d4f8dbdbbb3f3db6bd6a7f16f59a66d7ccd0b98635fbe555a4ba9e732ee6742a50863de76464239a55c9f25ce8f30714d766ec93b7a3e6dc4c7
• Download URL:
  https://stacks.cdc.gov/view/cdc/193386/cdc_193386_DS1.pdf
• File Type:
  [PDF - 479.84 KB ]