Rhinosinusitis and mold as risk factors for asthma symptoms in occupants of a water-damaged building

Details

• Personal Author:
  Cox-Ganser, Jean M. ; Kreiss, Kathleen ; Park, Ju-Hyeong ; Cox-Ganser, Jean M. ; Kreiss, Kathleen ; Park, Ju-Hyeong
• Description:
  Mold exposure in damp buildings is associated with both nasal symptoms and asthma development, but progression of building-related (BR) rhinosinusitis symptoms to asthma is unstudied. We examined risk of developing BR-asthma symptoms in relation to prior BR-rhinosinusitis symptoms and microbial exposure among occupants of a damp building. We conducted four cross-sectional health and environmental surveys among occupants of a 20-story water-damaged office building. We defined BR-rhinosinusitis symptom (n=131) and comparison (n=361) groups from participants' first questionnaire responses. We compared the odds for development of BR-asthma symptoms between these two groups over the subsequent surveys, using logistic regression models adjusted for demographics, smoking, building tenure, and first survey exposures to fungi, endotoxin, and ergosterol. The BR-rhinosinusitis symptom group had higher odds for developing BR-asthma symptoms [odds ratio (OR)=2.2; 95% confidence interval (CI)=1.3-3.6] in any subsequent survey compared to those without BR-rhinosinusitis symptoms. The BR-rhinosinusitis symptom group with higher fungal exposure within the building had an OR of 7.4 (95% CI=2.8-19.9) for developing BR-asthma symptoms, compared to the lower fungal exposure group without BR-rhinosinusitis symptoms. Our findings suggest that rhinosinusitis associated with occupancy of water-damaged buildings may be a sentinel for increased risk for asthma onset in such buildings. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Demography Endotoxins Fungi Microbiology Nose Occupational Health Respiratory Tract Diseases Risk Assessment Safety Sense Organs Smokers Surveys And Questionnaires

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• Keywords:
  Asthma Author Keywords: Rhinosinusitis Bronchial-asthma Demographic-characteristics Health-surveys Mathematical-models Microorganisms Microscopic-analysis Mold Exposure Molds Nasal-disorders Questionnaires Respiratory-system-disorders Risk-analysis Smoking

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• ISSN:
  0905-6947
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  396-404
• Volume:
  22
• Issue:
  5
• NIOSHTIC Number:
  nn:20040474
• Citation:
  Indoor Air 2012 Oct; 22(5):396-404
• Contact Point Address:
  Dr. Ju-Hyeong Park, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, MS 2800, 1095 Willowdale Rd., Morgantown, WV 26505-5820
• Email:
  gzp8@cdc.gov
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Services ; Services
• Peer Reviewed:
  True
• Source Full Name:
  Indoor Air
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:366f4998d4dec6cc630bdd4c2a8cc2a7f93e67b10f1ecca13da2fbab976ca86a317d72b12a1d17d01a43bbe2449b31734aa765fd2c0fafa6cd282579e357f429
• Download URL:
  https://stacks.cdc.gov/view/cdc/193315/cdc_193315_DS1.pdf
• File Type:
  [PDF - 248.02 KB ]