Determination of the extravascular burden of carbon monoxide (CO) on human heart

Details

• Personal Author:
  Erupaka K
• Description:
  Noninvasive measurements of myocardial carboxymyoglobin levels (%MbCO) and oxygen tensions (PtO2) are difficult to obtain experimentally. We have developed a compartmental model which allows prediction of myocardial %MbCO levels and PtO2 for varied carbon monoxide (CO) exposures. The cardiac compartment in the model consists of vascular subcompartments which contain two tissue subcompartments varying in capillary density. Mass-balance equations for oxygen (O2) and CO are applied for all compartments. Myocardial oxygen consumption and blood flow are quantified from predictive formulas based on heart rate. Model predictions are validated with experimental data at normoxia, hypoxia, exercise and hyperoxia. CO exposures of varying concentration and time (short-high, long-low), CO rebreathing during 100% O2, and exposure during exercise is simulated. Results of the simulations demonstrate that during CO exposures and subsequent therapies, the temporal changes of %MbCO in the heart differ from those of carboxyhemoglobin levels (%HbCO). Analysis of correlation between %HbCO, %MbCO and PtO2 was done to understand myocardial injury due to CO hypoxia. This thesis demonstrates that the model is able to anticipate the uptake and distribution of CO in the human myocardium and thus can be used to estimate the extravascular burden (MbCO, PtO2 ) of CO on the human heart. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Lung Lung Diseases Occupational Health Poisoning Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Myocardial Oxygen Tension Carbonyls Cardiac Cardiac-function Cardiopulmonary-system-disorders Cardiovascular-system-disease CO Hypoxia Exercise Exposure-levels Exposure-limits Heart Heart-rate Hypoxia Muscle Physical-exercise Poison-gases Poisons Tissue Oxygenation

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• Publisher:
  University of Kentucky
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Dissertation
• Place as Subject:
  Kentucky ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-148
• NIOSHTIC Number:
  nn:20040440
• Citation:
  Lexington, KY: University of Kentucky, 2008, Jan; :1-148
• Email:
  kinnerarey@uky.edu
• CAS Registry Number:
  Carbon monoxide (CAS RN 630-08-0)
• Federal Fiscal Year:
  2008
• Performing Organization:
  University of Kentucky
• Peer Reviewed:
  False
• Start Date:
  20060701
• Source Full Name:
  Determination of the extravascular burden of carbon monoxide (CO) on human heart
• End Date:
  20090630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2a9c828ac4b742dbc84da34f6083715a06d961857505ec837bb8e6829e1c0eb99ebd0454c26b8a85bb04bc21cb5d5db71cc400f1647df1dddaf75a79fb87e982
• Download URL:
  https://stacks.cdc.gov/view/cdc/193299/cdc_193299_DS1.pdf
• File Type:
  [PDF - 2.45 MB ]