Application of numerical methods for diffusion-based modeling of skin permeation

Details

• Personal Author:
  Barbero AM ; Frasch, H. Fredrick
• Description:
  The application of numerical methods for mechanistic, diffusion-based modeling of skin permeation is reviewed. Methods considered here are finite difference, method of lines, finite element, finite volume, random walk, cellular automata, and smoothed particle hydrodynamics. First the methods are briefly explained with rudimentary mathematical underpinnings. Current state of the art numerical models are described, and then a chronological overview of published models is provided. Key findings and insights of reviewed models are highlighted. Model results support a primarily transcellular pathway with anisotropic lipid. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety Skin Skin Absorption
• Keywords:
  Author Keywords: Transdermal Drug Delivery Cellular Automata Diffusion-analysis Finite Difference Method Finite Element Method Finite Volume Method Hydrodynamics Mathematical-models Method Of Lines Models Random Walk Skin-absorption Smoothed Particle Hydrodynamics Stratum Corneum Unit Cell Problem

  More +
• ISSN:
  0169-409X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  208-220
• Volume:
  65
• Issue:
  2
• NIOSHTIC Number:
  nn:20040218
• Citation:
  Adv Drug Deliv Rev 2013 Feb; 65(2):208-220
• Contact Point Address:
  H. Frederick Frasch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing ; Services
• Peer Reviewed:
  True
• Source Full Name:
  Advanced Drug Delivery Reviews
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bbaea4e62f3e0267e1601670d575e006b07060f642fe6bbdcd2b12d7127eca84c2d4d9cb0300a0f3440cbd98ec7a7595956a0bc4b909e06c841e043fcdc1d49c
• Download URL:
  https://stacks.cdc.gov/view/cdc/193162/cdc_193162_DS1.pdf
• File Type:
  [PDF - 599.88 KB ]