Early-life antecedents of atrial fibrillation: place of birth and atrial fibrillation-related mortality

Details

• Personal Author:
  Benjamin EJ ; Curtis LH ; Glymour MM ; Kosheleva A ; Patton KK
• Description:
  PURPOSE: Recent evidence suggests early-life factors correlate with atrial fibrillation (AF). We hypothesized that AF-related mortality, similar to stroke mortality, is elevated for individuals born in the southeastern United States. METHODS: We estimated 3-year (1999-2001) average AF-related mortality rates by using U.S. vital statistics for 55- to 89-year-old white (136,573 AF-related deaths) and black subjects (8,288 AF-related deaths). We estimated age- and sex-adjusted odds of AF-related (contributing cause) mortality associated with birth state, and birth within the U.S. stroke belt (SB), stratified by race. SB results were replicated with the use of 1989-1991 data. RESULTS: Among black subjects, four contiguous birth states were associated with statistically significant odds ratios = 1.25 compared with the national average AF-related mortality. The four highest-risk birth states for blacks also predicted elevated AF-related mortality among white subjects, but patterns were attenuated. The odds ratio for AF-related mortality associated with SB birth was 1.19 (confidence interval 1.13-1.25) for black and 1.09 (CI 1.07-1.12) for white subjects when we adjusted for SB adult residence. CONCLUSIONS: Place of birth predicted AF-related mortality, after we adjusted for place of adult residence. The association of AF-related mortality and SB birth parallels that of other cardiovascular diseases and may likewise indicate an importance of early life factors in the development of AF. [Description provided by NIOSH]
• Subjects:
  Aging Cardiovascular Diseases Cardiovascular System Environmental Health Longevity Men Mortality Occupational Health Race Factors Risk Assessment Risk Factors Safety Sex Characteristics Women

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• Keywords:
  Age-groups Author Keywords: Atrial Fibrillation Cardiac-function Cardiovascular-system Cardiovascular-system-disorders Environmental-factors Geographic Heart Humans Lifecourse Mortality Lifespan Mortality-data Mortality-rates Racial-factors Region-4 Residence Risk-analysis Risk-factors Sex-factors Statistical-analysis Vital-capacity

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• ISSN:
  1047-2797
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; North Carolina ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 4 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  21
• Issue:
  10
• NIOSHTIC Number:
  nn:20040144
• Citation:
  Ann Epidemiol 2011 Oct; 21(10):732-738
• Contact Point Address:
  Kristen K. Patton, MD, University of Washington Medical Center, 1959 NE Pacific Street, Box 356422, Seattle, WA 98195
• Email:
  krpatton@u.washington.edu
• Federal Fiscal Year:
  2012
• Performing Organization:
  Harvard University School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20080901
• Source Full Name:
  Annals of Epidemiology
• End Date:
  20110831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0f616c4ff60a82f2ba7ece23566b42bbc7983e8f69573025d212d741b5b228754afb1b78262bdb5f1336e37a7de5d00d581e94de5f3c20a727573b9d7fc2ea71
• Download URL:
  https://stacks.cdc.gov/view/cdc/193108/cdc_193108_DS1.pdf
• File Type:
  [PDF - 246.91 KB ]