Mass-spectrometric characterization of peroxidized and hydrolyzed lipids in plasma and dendritic cells of tumor-bearing animals

Details

• Personal Author:
  Cao W ; Gabrilovich DI ; Kagan VE ; Tyurin VA ; Tyurina YY
• Description:
  Dendritic cells are the most potent antigen presenting cells responsible for the development of immune responses in cancer. However, it is known that the function of dendritic cells in tumor-bearing hosts is severely compromised. Our previous studies demonstrated that the defects in dendritic cell function are due, to a large extent, to the accumulation of high amounts of lipids--predominantly triglycerides--in a substantial proportion of dendritic cells in tumor-bearing mice and patients with cancer. The dendritic cells accumulation of lipids is likely associated with their up-regulation of a scavenger receptor A. This receptor is primarily responsible for uptake of modified lipids. Here, by using different versions of liquid chromatography-mass spectrometry, we identified several molecular species of oxygenated lipids in plasma of tumor-bearing animals that may be responsible for their uptake and accumulation by dendritic cells via scavenger receptor A-dependent pathway--the effect that may be associated with the loss of dendritic cell's immune surveillance function in cancer. [Description provided by NIOSH]
• Subjects:
  Animals Antigens Chromatography Immune System Laboratories Lipids Mass Spectrometry Neoplasms Occupational Health Safety
• Keywords:
  Animal-studies Author Keywords: Cancer Cancer Cell-alteration Cellular-function Cellular-reactions Cellular-uptake Chromatographic-analysis Dendritic Cells Glycerides Immune-reaction Immune-system Laboratory-animals Laboratory-testing Lipid Uptake Mass-spectrometry Molecular-structure Oxygenated Fatty Acids Plasma Scavenger Receptor A Tumor-bearing Mice Tumors

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• ISSN:
  0006-291X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Florida ; OSHA Region 3 ; OSHA Region 4 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  149-153
• Volume:
  413
• Issue:
  1
• NIOSHTIC Number:
  nn:20039958
• Citation:
  Biochem Biophys Res Commun 2011 Sep; 413(1):149-153
• Contact Point Address:
  Valerian E. Kagan, Department of Environmental and Occupational Health, University of Pittsburgh, Bridgeside Point, 100 Technology Drive, Room 330, BRIDG, Pittsburgh, PA 15219-3130, USA
• Email:
  kagan@pitt.edu
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Biochemical and Biophysical Research Communications
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:85857a38dc0ef15edaeb493eb6160ab3b98006a6cccb3c4f6c6fe74ec591a3106461b28f1c5e63594ccffb064a9bfef7158bd7feed96a9a6e58238db511df460
• Download URL:
  https://stacks.cdc.gov/view/cdc/192985/cdc_192985_DS1.pdf
• File Type:
  [PDF - 349.46 KB ]