The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure

Details

• Personal Author:
  Borisova T ; Butler MA ; Chao Y-CE ; Egeghy P ; Frame L ; French JE ; Kang-Sickel-J-CC ; Li W ; Nylander-French LA ; Rappaport SM ; Serdar B ; Toennis CA
• Description:
  We investigated the association between biomarkers of dermal exposure, naphthyl-keratin adducts (NKA), and urine naphthalene biomarker levels in 105 workers routinely exposed to jet-fuel. A moderate correlation was observed between NKA and urine naphthalene levels (p=0.061). The NKA, post-exposure breath naphthalene, and male gender were associated with an increase, while CYP2E1*6 DD and GSTT1-plus (++/+-) genotypes were associated with a decrease in urine naphthalene level (p<0.0001). The NKA show great promise as biomarkers for dermal exposure to naphthalene. Further studies are warranted to characterize the relationship between NKA, other exposure biomarkers, and/or biomarkers of biological effects due to naphthalene and/or PAH exposure. [Description provided by NIOSH]
• Subjects:
  Biomarkers Fuel Oils Naphthalenes Occupational Health Safety Skin Urine
• Keywords:
  1-naphthol 2-naphthol Author Keywords: Biomarkers CYP2E1 Dermal Exposure Exposure-levels Exposure-limits Fuels Glutathione S-transferase Mu 1 (GSTM1) Glutathione S-transferase Theta 1 (GSTT1) Jet Fuel (JP-8) Keratin Adduct NAD(P)H:quinone Oxidoreductase (NQO1) Naphthalene Skin-exposure Skin-irritants Skin-sensitivity Urinalysis Urine

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• ISSN:
  1354-750X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 8 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  7
• NIOSHTIC Number:
  nn:20039947
• Citation:
  Biomarkers 2011 Nov; 16(7):590-599
• Contact Point Address:
  Leena A. Nylander-French, Ph.D., CIH, Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, CB #7431, Rosenau Hall, Chapel Hill, NC 27599-7431
• Email:
  leena_french@unc.edu
• CAS Registry Number:
  Naphthalene (CAS RN 91-20-3)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Healthcare and Social Assistance ; Services ; Manufacturing
• Performing Organization:
  University of North Carolina, Chapel Hill
• Peer Reviewed:
  True
• Start Date:
  20000701
• Source Full Name:
  Biomarkers
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9006dca5ec2d92ff0bc479eb9fe8b13c6db372ee60a129866ee0d2745d68b1a492850694ce8a2505d0da8f4d9495745c58d085634466fef8054fdbd7fe1b2683
• Download URL:
  https://stacks.cdc.gov/view/cdc/192983/cdc_192983_DS1.pdf
• File Type:
  [PDF - 619.03 KB ]