Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials

Details

• Personal Author:
  Contreras EQ ; Hartung T ; Hirsch C ; Hogberg H ; Jachak AC ; Jordan W ; Landsiedel R ; Morris J ; Patri A ; Pounds JG ; Ruiz AD ; Shvedova A ; Silbergeld EK ; Tanguay R ; Tatarazako N ; van Vliet E ; Walker NJ ; Wiesner M ; Wilcox N ; Zurlo J
• Description:
  In October 2010, a group of experts met as part of the transatlantic think tank for toxicology (t4) to exchange ideas about the current status and future of safety testing of nanomaterials. At present, there is no widely accepted path forward to assure appropriate and effective hazard identification for engineered nanomaterials. The group discussed needs for characterization of nanomaterials and identified testing protocols that incorporate the use of innovative alternative whole models such as zebrafish or C. elegans, as well as in vitro or alternative methods to examine specific functional pathways and modes of action. The group proposed elements of a potential testing scheme for nanomaterials that works towards an integrated testing strategy, incorporating the goals of the NRC report Toxicity Testing in the 21st Century: A Vision and a Strategy by focusing on pathways of toxic response, and utilizing an evidence-based strategy for developing the knowledge base for safety assessment. Finally, the group recommended that a reliable, open, curated database be developed that interfaces with existing databases to enable sharing of information. [Description provided by NIOSH]
• Subjects:
  Animals Hazardous Substances Occupational Health Safety Safety Management Toxicology
• Keywords:
  3Rs Alternative Methods Author Keywords: Nanomaterials Nanotechnology Nanotoxicology Safety-measures Tox-21c Toxic-effects Toxins
• ISSN:
  1868-596X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; Maryland ; North Carolina ; Oregon ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 6 ; Texas ; Washington ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  236-241
• Volume:
  28
• Issue:
  3
• NIOSHTIC Number:
  nn:20039842
• Citation:
  ALTEX 2011 Mar; 28(3):236-241
• Contact Point Address:
  Joanne Zurlo, PhD The Johns Hopkins Center for Alternatives to Animal Testing, 615 North Wolfe Street, W7032, Baltimore, MD 21205
• Email:
  jzurlo@jhsph.edu
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  ALTEX Alternatives to Animal Experimentation
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d495ddfd71e2ab03a78770581a1d79cbba32a634bcb8076ab234726f929b1d74f0c3c13d8bb28aea652bc265cd151899e9df1cbca94b8eaac5662ee948de9707
• Download URL:
  https://stacks.cdc.gov/view/cdc/192913/cdc_192913_DS1.pdf
• File Type:
  [PDF - 370.31 KB ]