The Differential Effects of the Herbicide Banvel (Dicamba) on Peroxisomal and Cytochrome P-450 Activities

Details

• Personal Author:
  Espandiari P ; Robertson LW ; Thomas VA
• Description:
  The widely used broad leaf herbicide Banvel is similar in structure to xenobiotics which induce hepatic drug metabolism or proliferation of hepatic peroxisomes. The ability of xenobiotics to effect these hepatic changes often portends their positive outcomes in rodent chronic bioassays. Banvel's ability to induce hepatomegaly, peroxisome proliferation and drug metabolism was studied in male and female Sprague Dawley rats. Rats were placed on feed containing 0.001, 0.01, 0.1, and 1% Banvel or 0.01% ciprofibnate for 3 weeks. Banvel had no effect on relative liver weight or feed efficiency in either female or male rats at all doses tested. Banvel caused a statistically significant increase in peroxisomal B-oxidation in female rats only at 1 % dietary level. Banvel significantly decreased ethoxyresondin O-deethylase activity at several doses while benzoloxyresorufin O-debenzylase activity was increased at the highest dose of Banvel in both female and male rats. Lauric acid hydroxylase activity was increased in microsomes from male rats fed the highest level of Banvel. [Description provided by NIOSH]
• Subjects:
  Animals Diet Environmental Monitoring Hazardous Substances Herbicides Laboratories Occupational Health Safety Toxicology
• Keywords:
  Animal-studies Dietary-effects Exposure-assessment Exposure-levels Laboratory-animals Laboratory-testing Toxic-effects Toxins
• ISSN:
  0731-9193
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  1
• NIOSHTIC Number:
  nn:20035554
• Citation:
  Toxicologist 1994 Mar; 14(1):388
• CAS Registry Number:
  Dicamba (CAS RN 1918-00-9)
• Federal Fiscal Year:
  1994
• Performing Organization:
  University of Kentucky, Department of Preventive Medicine, Lexington, KY
• Peer Reviewed:
  False
• Start Date:
  19920930
• Source Full Name:
  The Toxicologist. Society of Toxicology 33rd Annual Meeting, March 13-17, 1994, Dallas, Texas
• End Date:
  20020929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c43a717a209abe4c7aa0e3c18a17ac29c63468f39167cf61a196b74a0930bd909ef2349e927bc8cbb21a2edf3347e34525cf4ab173509f35af44a64e7acb7a8f
• Download URL:
  https://stacks.cdc.gov/view/cdc/187378/cdc_187378_DS1.pdf
• File Type:
  [PDF - 226.75 KB ]