Longitudinal lung function declines among California flavoring manufacturing workers

Details

• Personal Author:
  Enright, Paul L. ; Fedan, Kathleen B. ; Kim TJ ; Kreiss, Kathleen ; Materna BL ; Nasrullah M ; Prudhomme JC
• Description:
  Background The California Department of Public Health received serial spirometry data for flavoring manufacturing workers at 20 companies at risk of bronchiolitis obliterans. Methods We graded spirometry quality; identified individual workers with excessive decline in forced expiratory volume in 1 s (FEV1) using relative longitudinal limits of decline based on 4% average within-person variability; and analyzed declines by occupational risk factors. Results The quality of 1,697 spirometry tests from 725 workers varied by 18 providers, with poorer quality from commercial providers. Of 416 workers with at least two tests, 40 (9.6%) had abnormal FEV1 decline. Of 289 workers with high quality spirometry, 21 (7.3%) had abnormal decline. Only one of the 21 had airways obstruction. Abnormal FEV1 decline rates (per person-month) were greater among workers at companies using greater than or equal to 800 lbs/year diacetyl than at companies using lesser amounts. Abnormal FEV1 decline rates were greater at companies previously having four-person clusters of spirometric obstruction than at companies with no or only one worker with obstruction. Conclusions Spirometric surveillance of flavoring workers can identify individual workers with an abnormal FEV1 decline for preventive intervention, even when the FEV1 itself remains within the normal range. Good quality spirometry and classification of abnormal with relative longitudinal limit of decline minimize misclassification of possible work-related health effects. [Description provided by NIOSH]
• Subjects:
  Irritants Lung Lung Diseases Occupational Health Respiratory Function Tests Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Bronchiolitis Obliterans Diacetyl Flavoring Lung-disease Lung-disorders Lung-function Lung-irritants Occupational-respiratory-disease Pulmonary-disorders Pulmonary-function Pulmonary-function-tests Pulmonary-system Pulmonary-system-disorders Quantitative-analysis Respiratory-function-tests Respiratory-hypersensitivity Respiratory-irritants Respiratory-system-disorders Spirometry Statistical-analysis Surveillance

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  55
• Issue:
  8
• NIOSHTIC Number:
  nn:20039724
• Citation:
  Am J Ind Med 2012 Aug; 55(8):657-668
• Contact Point Address:
  Kathleen Kreiss, MD, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road Mailstop H-2800,Morgantown,WV 26505
• Email:
  kkreiss@cdc.gov
• Federal Fiscal Year:
  2012
• Performing Organization:
  Public Health Institute
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c50ffd65f55963567dd543d17bf61679ade352e4eac961bfdf9e60f9cbfa9e9495b48ebccd917bf22f866fe25769e90e9104698eee6284af340666cb05a4704f
• Download URL:
  https://stacks.cdc.gov/view/cdc/192856/cdc_192856_DS1.pdf
• File Type:
  [PDF - 130.57 KB ]