Acute effects of COREXIT EC9500A on cardiovascular functions in rats

Details

• Personal Author:
  Castranova, Vincent ; Frazer D ; Goldsmith WT ; Jackson M ; Johnson C ; Kan H ; Kashon ML ; Krajnak, Kristine M. ; McKinney W ; Miller, G. Roger ; Roberts, Jennifer R. ; Waugh, Stacey
• Description:
  These studies characterized cardiovascular responses after an acute inhalation exposure to COREXIT EC9500A, the oil dispersant used in the Deepwater Horizon oil spill. Male Sprague-Dawley rats underwent a single 5-h inhalation exposure to COREXIT EC9500A (average exposure level 27.12 mg/m(3)) or air. On d 1 and 7 following the exposure, rats were implanted with indwelling catheters and changes in heart rate and blood pressure were assessed in response to increasing levels of adrenoreceptor agonists. A separate group of rats was euthanized at the same time points, ventral tail arteries were dissected, and vascular tone along with dose-dependent responses to vasoconstricting and dilating factors were assessed in vitro. Agonist-induced dose-dependent increases in heart rate and blood pressure were greater in COREXIT EC9500A-exposed than in air-exposed rats at 1 d but not 7 d after the exposure. COREXIT EC9500A exposure also induced a rise in basal tone and reduced responsiveness of tail arteries to acetylcholine-induced vasodilation at 1 d but not 7 d following the exposure. These findings demonstrate that an acute exposure to COREXIT EC9500A exerts transient effects on cardiovascular and peripheral vascular functions. [Description provided by NIOSH]
• Subjects:
  Animals Blood Cardiovascular Diseases Cardiovascular System Environmental Monitoring Hazardous Substances Inhalation Exposure Laboratories Occupational Health Petroleum Respiratory System Safety

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• Keywords:
  Acute-toxicity Animal-studies Blood-pressure Cardiovascular-function Cardiovascular-function-tests Cardiovascular-system Cardiovascular-system-disorders Chemical-cleaning Cleaning-compounds Crude-oil Dispersion Dose-response Exposure-assessment Exposure-levels Exposure-methods Heart Heart-rate In-vitro-study Inhalants Inhalation-studies Laboratory-animals Laboratory-testing Oils Petroleum-oils Petroleum-products

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• ISSN:
  1528-7394
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  74
• Issue:
  21
• NIOSHTIC Number:
  nn:20039686
• Citation:
  J Toxicol Environ Health A 2011 Nov; 74(21):1397-1404
• Contact Point Address:
  Kristine Krajnak, PhD, Engineering and Controls Technology Branch, Health Effects Laboratory Division, 1095 Willowdale Rd, MS2027, Morgantown WV 26505, USA
• Email:
  ksk1@cdc.gov
• CAS Registry Number:
  1-(1-Butoxy-2-propoxy)-2-propanol (CAS RN 29911-28-2) ; Distillates (petroleum), hydrotreated light (CAS RN 64742-47-8) ; Polyethylene glycol sorbitan trioleate (CAS RN 9005-70-3) ; Polyoxyethylene sorbitan monooleate (CAS RN 9005-65-6) ; Sodium bis(2-ethylhexyl) sulfosuccinate (CAS RN 577-11-7) ; Sorbitan mono-(9Z)-9-octadecenoate (CAS RN 1338-43-8)
• Federal Fiscal Year:
  2012
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d2ca3782737017be3672a642392c2c7ed44f1d7c79aae8644c0e4d83a3cd802dadcc238405e97b732a2b901c5a1c7c96e129d8461e33cee1c27263f48881e626
• Download URL:
  https://stacks.cdc.gov/view/cdc/192840/cdc_192840_DS1.pdf
• File Type:
  [PDF - 260.16 KB ]