Biomarkers of sensitivity and exposure in Washington State pesticide handlers

Details

• Personal Author:
  Checkoway, Harvey ; De Roos AJ ; Farin FM ; Fenske RA ; Furlong CE ; Hofmann JN ; Keifer MC ; Richter RJ ; van Belle G
• Description:
  Organophosphate (OP) and N-methyl-carbamate (CB) insecticides are widely used in agriculture in the US and abroad. These compounds - which inhibit acetylcholinestersase (AChE) enzyme activity - continue to be responsible for a high proportion of pesticide poisonings among US agricultural workers. It is possible that some individuals may be especially susceptible to health effects related to OP/CB exposure. The paraoxonase (PON1) enzyme metabolizes the highly toxic oxon forms of some OPs, and an individual's PON1 status may be an important determinant of his or her sensitivity to these chemicals. This chapter discusses methods used to characterize the PON1 status of individuals and reviews previous epidemiologic studies that have evaluated PON1-related sensitivity to OPs in relation to various health endpoints. It also describes an ongoing longitudinal study among OP-exposed agricultural pesticide handlers who are participating in a recently implemented cholinesterase monitoring program in Washington state. This study will evaluate handlers' PON1 status as a hypothesized determinant of butyrylcholinesterase (BuChE) inhibition. Such studies will be useful to determine how regulatory risk assessments might account for differences in PON1-related OP sensitivity when characterizing inter-individual variability in risk related to OP exposure. Recent work assessing newer and more sensitive biomarkers of OP exposure is also discussed briefly in this chapter. [Description provided by NIOSH]
• Subjects:
  Agriculture Biomarkers Carbamates Enzymes Family Farmers Hazardous Substances Insecticides Occupational Health Poisoning Safety

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• Keywords:
  Acetylcholinesterase Agricultural-workers Author Keywords: Agriculture Cholinesterase Enzyme-activity Families Farm Workers Gene-environment Interaction Hazardous-materials Organophosphates Organophosphorus-pesticides Paraoxonase Pesticides Pesticides-and-agricultural-chemicals Poisons PON1

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• ISBN:
  9781607613497
• ISSN:
  0065-2598
• Publisher:
  Springer
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 10 ; OSHA Region 3 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  19-27
• Volume:
  660
• NIOSHTIC Number:
  nn:20039656
• Citation:
  Adv Exp Med Biol 2010 Jan; 660:19-27
• Contact Point Address:
  J.N. Hofmann, Division of Cancer Epidemilogy and Genetics, National Cancer Institute, Bethesda, MD, USA
• Email:
  hofmannjn@mail.nih.gov
• CAS Registry Number:
  Carbamic acid, methyl ester (CAS RN 598-55-0)
• Editor(s):
  Reddy ST
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Advances in Experimental Medicine and Biology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f7684a839b986af9f65d8d2d644a787a0164fe8b87b29db3e8ec296451289dd8ce00c6bd2f84b6c2a517525891196fd3bb68c169ef94084a0a8a7af50581a2db
• Download URL:
  https://stacks.cdc.gov/view/cdc/192822/cdc_192822_DS1.pdf
• File Type:
  [PDF - 400.64 KB ]